B6QV51 · B6QV51_TALMQ
- ProteinFormate dehydrogenase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids406 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the NAD+-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.
Catalytic activity
- formate + NAD+ = CO2 + NADH
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 137 | substrate | |||
Binding site | 163 | substrate | |||
Binding site | 218-219 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 239 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 274-278 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 300 | NAD+ (UniProtKB | ChEBI) | |||
Site | 302 | Important for catalytic activity | |||
Binding site | 326 | NAD+ (UniProtKB | ChEBI) | |||
Site | 355 | Important for catalytic activity | |||
Binding site | 355-358 | NAD+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | formate dehydrogenase (NAD+) activity | |
Molecular Function | NAD binding | |
Molecular Function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | |
Biological Process | formate catabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFormate dehydrogenase
- EC number
- Short namesFDH
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Trichocomaceae > Talaromyces > Talaromyces sect. Talaromyces
Accessions
- Primary accessionB6QV51
Proteomes
Organism-specific databases
Subcellular Location
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 77-172 | D-isomer specific 2-hydroxyacid dehydrogenase catalytic | |||
Domain | 173-343 | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding | |||
Sequence similarities
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length406
- Mass (Da)44,706
- Last updated2008-12-16 v1
- MD5 ChecksumF68A73289F27A392809603F97BC0BFE4
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
B6QV50 | B6QV50_TALMQ | PMAA_011780 | 363 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DS995906 EMBL· GenBank· DDBJ | EEA18902.1 EMBL· GenBank· DDBJ | Genomic DNA |