B6QG32 · CHO2_TALMQ

Function

function

Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).

Catalytic activity

Pathway

Phospholipid metabolism; phosphatidylcholine biosynthesis.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionphosphatidylethanolamine N-methyltransferase activity
Biological Processmethylation
Biological Processphosphatidylcholine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphatidylethanolamine N-methyltransferase
  • EC number
  • Short names
    PE methyltransferase
    ; PEAMT
    ; PEMT

Gene names

    • Name
      cho2
    • ORF names
      PMAA_084230

Organism names

Accessions

  • Primary accession
    B6QG32

Proteomes

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-84Lumenal
Transmembrane85-105Helical
Topological domain106-111Cytoplasmic
Transmembrane112-132Helical
Topological domain133-197Lumenal
Transmembrane198-218Helical
Topological domain219-225Cytoplasmic
Transmembrane226-246Helical
Topological domain247-279Lumenal
Transmembrane280-300Helical
Topological domain301-302Cytoplasmic
Transmembrane303-323Helical
Topological domain324-403Lumenal
Transmembrane404-424Helical
Topological domain425-426Cytoplasmic
Transmembrane427-447Helical
Topological domain448-477Lumenal
Transmembrane478-497Helical
Topological domain498-524Cytoplasmic
Transmembrane525-545Helical
Topological domain546-581Lumenal
Transmembrane582-602Helical
Topological domain603-992Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004059051-992Phosphatidylethanolamine N-methyltransferase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-27Disordered
Region41-60Disordered
Region708-733Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    992
  • Mass (Da)
    112,150
  • Last updated
    2008-12-16 v1
  • Checksum
    41437D374BDEEE21
MDSASASGAQRQDEGLRERMRPSPPVDIDAVDQALATAGYGVTTDNRTSDDKKTFGRTPDGTIFTVPQTHDMVSQLLSPTEPKNVSDLLVLAILAVHILIFWALSPQSRIPVFAAIYMFWRTSYNGGIGWLLHNQSHHNTMVRWATKSKIFVNPSTGKNPRPILYRLLKKDMETMIPKDYSFDEAPLEYNTWLVFRRFVDVILMCDFTSYCLFAIACGSRPENETTLMTALRWAAGWVLVIFNLWVKLDAHRVVKDFAWYWGDFFFLIDQELTFDGVFEMAPHPMYSVGYAGYYGISLMAASYKVLFISIIAHAAQFAFLVLVENPHIDRVYNPPPPRKRSVQHDLKDLNGFNAQTSPISDSFAATPAPNGIDDKASMQQPPSSVHNLLGLHNLDLHRVTDSSVILIQLLVFALTVLTPSTPFYQYLFVANAAIWRCWYSIGIGYILHRQSKYKSWTRHFVKYGENTDEAWRQWKGSYHLSMTMCYASFVAATWKMYSMPSDWNHGLALLKHTLGFSLAALQIWTSVSIYDSLGEFGWFFGDFFFDAQSKLTYSGIYRFLNNPERVLGLAGLWGAALITSKGAIIFLALISHILTLAFIQLVERPHMQKLYGRSLRKDAGLVKNLKRSLPPPLQQLGGSVDRIMDESFEFVEELLDSARPKLATGVNTFMKDAKSLFRQYPARITISRLDDEVAAGYNLEDYSLEIEGTESSPSAQVERSSGKEGANARAPPERRGDLKSLIFEYGAPIRVKWTAPLNHSKKDWVGLYMVTDNTRREVTRISSQGRWIATNEGAYDSLTCEKGLVTSDIVISASRRRDGENRDLASGEMVFSGDKLFWTQGVFEFRYHHNGKHNVMAISRPFEIRIGRFDEEDVVDMDNTTANSDGLIQAAIEEALLPVVRNCFDRNPEIAPETYDEHFGSLVDRDGKYAKRVVFAVHQMFGVELAPEVVRADGNVRNMAWRICNAKKVLAPYSMSRSRGTTTPTTQEKELS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS995901
EMBL· GenBank· DDBJ
EEA24417.1
EMBL· GenBank· DDBJ
Genomic DNA

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