B6QG32 · CHO2_TALMQ
- ProteinPhosphatidylethanolamine N-methyltransferase
- Genecho2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids992 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H+
Pathway
Phospholipid metabolism; phosphatidylcholine biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | phosphatidylethanolamine N-methyltransferase activity | |
Biological Process | methylation | |
Biological Process | phosphatidylcholine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphatidylethanolamine N-methyltransferase
- EC number
- Short namesPE methyltransferase ; PEAMT ; PEMT
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Trichocomaceae > Talaromyces > Talaromyces sect. Talaromyces
Accessions
- Primary accessionB6QG32
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-84 | Lumenal | ||||
Sequence: MDSASASGAQRQDEGLRERMRPSPPVDIDAVDQALATAGYGVTTDNRTSDDKKTFGRTPDGTIFTVPQTHDMVSQLLSPTEPKN | ||||||
Transmembrane | 85-105 | Helical | ||||
Sequence: VSDLLVLAILAVHILIFWALS | ||||||
Topological domain | 106-111 | Cytoplasmic | ||||
Sequence: PQSRIP | ||||||
Transmembrane | 112-132 | Helical | ||||
Sequence: VFAAIYMFWRTSYNGGIGWLL | ||||||
Topological domain | 133-197 | Lumenal | ||||
Sequence: HNQSHHNTMVRWATKSKIFVNPSTGKNPRPILYRLLKKDMETMIPKDYSFDEAPLEYNTWLVFRR | ||||||
Transmembrane | 198-218 | Helical | ||||
Sequence: FVDVILMCDFTSYCLFAIACG | ||||||
Topological domain | 219-225 | Cytoplasmic | ||||
Sequence: SRPENET | ||||||
Transmembrane | 226-246 | Helical | ||||
Sequence: TLMTALRWAAGWVLVIFNLWV | ||||||
Topological domain | 247-279 | Lumenal | ||||
Sequence: KLDAHRVVKDFAWYWGDFFFLIDQELTFDGVFE | ||||||
Transmembrane | 280-300 | Helical | ||||
Sequence: MAPHPMYSVGYAGYYGISLMA | ||||||
Topological domain | 301-302 | Cytoplasmic | ||||
Sequence: AS | ||||||
Transmembrane | 303-323 | Helical | ||||
Sequence: YKVLFISIIAHAAQFAFLVLV | ||||||
Topological domain | 324-403 | Lumenal | ||||
Sequence: ENPHIDRVYNPPPPRKRSVQHDLKDLNGFNAQTSPISDSFAATPAPNGIDDKASMQQPPSSVHNLLGLHNLDLHRVTDSS | ||||||
Transmembrane | 404-424 | Helical | ||||
Sequence: VILIQLLVFALTVLTPSTPFY | ||||||
Topological domain | 425-426 | Cytoplasmic | ||||
Sequence: QY | ||||||
Transmembrane | 427-447 | Helical | ||||
Sequence: LFVANAAIWRCWYSIGIGYIL | ||||||
Topological domain | 448-477 | Lumenal | ||||
Sequence: HRQSKYKSWTRHFVKYGENTDEAWRQWKGS | ||||||
Transmembrane | 478-497 | Helical | ||||
Sequence: YHLSMTMCYASFVAATWKMY | ||||||
Topological domain | 498-524 | Cytoplasmic | ||||
Sequence: SMPSDWNHGLALLKHTLGFSLAALQIW | ||||||
Transmembrane | 525-545 | Helical | ||||
Sequence: TSVSIYDSLGEFGWFFGDFFF | ||||||
Topological domain | 546-581 | Lumenal | ||||
Sequence: DAQSKLTYSGIYRFLNNPERVLGLAGLWGAALITSK | ||||||
Transmembrane | 582-602 | Helical | ||||
Sequence: GAIIFLALISHILTLAFIQLV | ||||||
Topological domain | 603-992 | Cytoplasmic | ||||
Sequence: ERPHMQKLYGRSLRKDAGLVKNLKRSLPPPLQQLGGSVDRIMDESFEFVEELLDSARPKLATGVNTFMKDAKSLFRQYPARITISRLDDEVAAGYNLEDYSLEIEGTESSPSAQVERSSGKEGANARAPPERRGDLKSLIFEYGAPIRVKWTAPLNHSKKDWVGLYMVTDNTRREVTRISSQGRWIATNEGAYDSLTCEKGLVTSDIVISASRRRDGENRDLASGEMVFSGDKLFWTQGVFEFRYHHNGKHNVMAISRPFEIRIGRFDEEDVVDMDNTTANSDGLIQAAIEEALLPVVRNCFDRNPEIAPETYDEHFGSLVDRDGKYAKRVVFAVHQMFGVELAPEVVRADGNVRNMAWRICNAKKVLAPYSMSRSRGTTTPTTQEKELS |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000405905 | 1-992 | Phosphatidylethanolamine N-methyltransferase | |||
Sequence: MDSASASGAQRQDEGLRERMRPSPPVDIDAVDQALATAGYGVTTDNRTSDDKKTFGRTPDGTIFTVPQTHDMVSQLLSPTEPKNVSDLLVLAILAVHILIFWALSPQSRIPVFAAIYMFWRTSYNGGIGWLLHNQSHHNTMVRWATKSKIFVNPSTGKNPRPILYRLLKKDMETMIPKDYSFDEAPLEYNTWLVFRRFVDVILMCDFTSYCLFAIACGSRPENETTLMTALRWAAGWVLVIFNLWVKLDAHRVVKDFAWYWGDFFFLIDQELTFDGVFEMAPHPMYSVGYAGYYGISLMAASYKVLFISIIAHAAQFAFLVLVENPHIDRVYNPPPPRKRSVQHDLKDLNGFNAQTSPISDSFAATPAPNGIDDKASMQQPPSSVHNLLGLHNLDLHRVTDSSVILIQLLVFALTVLTPSTPFYQYLFVANAAIWRCWYSIGIGYILHRQSKYKSWTRHFVKYGENTDEAWRQWKGSYHLSMTMCYASFVAATWKMYSMPSDWNHGLALLKHTLGFSLAALQIWTSVSIYDSLGEFGWFFGDFFFDAQSKLTYSGIYRFLNNPERVLGLAGLWGAALITSKGAIIFLALISHILTLAFIQLVERPHMQKLYGRSLRKDAGLVKNLKRSLPPPLQQLGGSVDRIMDESFEFVEELLDSARPKLATGVNTFMKDAKSLFRQYPARITISRLDDEVAAGYNLEDYSLEIEGTESSPSAQVERSSGKEGANARAPPERRGDLKSLIFEYGAPIRVKWTAPLNHSKKDWVGLYMVTDNTRREVTRISSQGRWIATNEGAYDSLTCEKGLVTSDIVISASRRRDGENRDLASGEMVFSGDKLFWTQGVFEFRYHHNGKHNVMAISRPFEIRIGRFDEEDVVDMDNTTANSDGLIQAAIEEALLPVVRNCFDRNPEIAPETYDEHFGSLVDRDGKYAKRVVFAVHQMFGVELAPEVVRADGNVRNMAWRICNAKKVLAPYSMSRSRGTTTPTTQEKELS |
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-27 | Disordered | ||||
Sequence: MDSASASGAQRQDEGLRERMRPSPPVD | ||||||
Region | 41-60 | Disordered | ||||
Sequence: GVTTDNRTSDDKKTFGRTPD | ||||||
Region | 708-733 | Disordered | ||||
Sequence: GTESSPSAQVERSSGKEGANARAPPE |
Sequence similarities
Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length992
- Mass (Da)112,150
- Last updated2008-12-16 v1
- Checksum41437D374BDEEE21
Keywords
- Technical term