B6KJ32 · RON4_TOXGO
- ProteinRhoptry neck protein 4
- GeneRON4
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids984 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | symbiont-containing vacuole membrane |
Names & Taxonomy
Protein names
- Recommended nameRhoptry neck protein 4
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Conoidasida > Coccidia > Eucoccidiorida > Eimeriorina > Sarcocystidae > Toxoplasma
Accessions
- Primary accessionB6KJ32
- Secondary accessions
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Located prominently at the junction of the body and neck portion of the rhoptry organelle in tachyzoites and bradyzoites. Upon infection, associates with the parasitophorous vacuolar membrane (PVM).
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-26 | |||||
Sequence: MAIKNTLTGSGLLVLLTLACGTTVQS | ||||||
Chain | PRO_0000398814 | 27-984 | Rhoptry neck protein 4 | |||
Sequence: SPPTPAPRMYPNMNERPLSAESRLTPGTYRSELHIDLKSPQKTASQSSLAPTGDNNSKVESIIAGSDTTPRSAEGTSESPPVPQLGTPPRPAPRRSKGEGERQPPTAAPRTSRSVDTGSGSDASTEQQAGGQKVVTPIPASKGIYPSLDELRRSQESNVDAGSGTSTNEGGGTSEGPQVPQSGIPPRTGRRRAKARNRKRHPTPASRESSSEDENQPPTTASRPSNGEGESQPPTAAPRTSRSVDTGSGSDASTEQQAGGQKVVTPIPASKGIYPNLDELRQTQEGEESAPQPADVTWFSMSVPMGVVDRRVSRALKEQFFQFLQHLSADYPKQVQTVYEFLGWVADKLPENEEEVQMFIDALNTTEAMVGKAARWIFKAIPERERETIYSSFYQMFRDKLPKKFFETAEGMNPDVGQYFSAEEPVAVTPEIPAKSEEDSEAAETPTPLRRQANVAAQVLHPLPAKGVTRREWIPWPKMQNAISKAHGPLTRVPEWTPVTGSCALGDGYTDIDVTKATTDVLFRITLLILQQIRRKKTERGKLEDDQALVALCSAAGAFVDAWQHQQQALILEDPGTPKAHAQLIERLRNAGKYFMKSYDETTGESDHQQWKKNKAEVSKLGKSALMKSCVKYIKASGDVATRPFDSGTAKYPSRSLYGGIANTLETPFADSEAVAKAVHDYAKEHKKPEKLVGLCGALQISGYFKKCFSDAGRLSSVSFFHQHVDGASVLVRTLARERPIGRHALSQAICDPNISAQYFEGAFRLFSSTVSQEWEKENLFAQLASWTGKEMVLAPSLEEQAAVPPAQPAYETVYGDEEDRIYRIHVSGRHSSPQEVLYVGGIPSTVKPQQVHVLGPTVSDESRRMIHPVRHRSRTAPSSEAASTAAESSDEDPLPAENATAFLGVTPQEEESDAYKHTLDFDAVSPRKNKNKENRISAPLKQSDTLIEESTSKTSEL | ||||||
Glycosylation | 81 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 390 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 780 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 925 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
PTM databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 24-300 | Disordered | ||||
Sequence: VQSSPPTPAPRMYPNMNERPLSAESRLTPGTYRSELHIDLKSPQKTASQSSLAPTGDNNSKVESIIAGSDTTPRSAEGTSESPPVPQLGTPPRPAPRRSKGEGERQPPTAAPRTSRSVDTGSGSDASTEQQAGGQKVVTPIPASKGIYPSLDELRRSQESNVDAGSGTSTNEGGGTSEGPQVPQSGIPPRTGRRRAKARNRKRHPTPASRESSSEDENQPPTTASRPSNGEGESQPPTAAPRTSRSVDTGSGSDASTEQQAGGQKVVTPIPASKGIY | ||||||
Compositional bias | 64-107 | Polar residues | ||||
Sequence: KSPQKTASQSSLAPTGDNNSKVESIIAGSDTTPRSAEGTSESPP | ||||||
Repeat | 129-172 | 1 | ||||
Sequence: QPPTAAPRTSRSVDTGSGSDASTEQQAGGQKVVTPIPASKGIYP | ||||||
Compositional bias | 133-160 | Polar residues | ||||
Sequence: AAPRTSRSVDTGSGSDASTEQQAGGQKV | ||||||
Compositional bias | 183-207 | Polar residues | ||||
Sequence: SNVDAGSGTSTNEGGGTSEGPQVPQ | ||||||
Compositional bias | 235-289 | Polar residues | ||||
Sequence: SSSEDENQPPTTASRPSNGEGESQPPTAAPRTSRSVDTGSGSDASTEQQAGGQKV | ||||||
Repeat | 258-301 | 2 | ||||
Sequence: QPPTAAPRTSRSVDTGSGSDASTEQQAGGQKVVTPIPASKGIYP | ||||||
Region | 882-984 | Disordered | ||||
Sequence: GPTVSDESRRMIHPVRHRSRTAPSSEAASTAAESSDEDPLPAENATAFLGVTPQEEESDAYKHTLDFDAVSPRKNKNKENRISAPLKQSDTLIEESTSKTSEL | ||||||
Compositional bias | 937-964 | Basic and acidic residues | ||||
Sequence: EESDAYKHTLDFDAVSPRKNKNKENRIS | ||||||
Compositional bias | 965-984 | Polar residues | ||||
Sequence: APLKQSDTLIEESTSKTSEL |
Keywords
- Domain
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 2 isoforms produced by Alternative splicing.
B6KJ32-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length984
- Mass (Da)107,238
- Last updated2014-04-16 v2
- Checksum1CD7AD28A68789F4
B6KJ32-2
- Name2
- Differences from canonical
- 1-394: Missing
Sequence caution
Features
Showing features for alternative sequence, compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_039809 | 1-394 | in isoform 2 | |||
Sequence: Missing | ||||||
Compositional bias | 64-107 | Polar residues | ||||
Sequence: KSPQKTASQSSLAPTGDNNSKVESIIAGSDTTPRSAEGTSESPP | ||||||
Compositional bias | 133-160 | Polar residues | ||||
Sequence: AAPRTSRSVDTGSGSDASTEQQAGGQKV | ||||||
Compositional bias | 183-207 | Polar residues | ||||
Sequence: SNVDAGSGTSTNEGGGTSEGPQVPQ | ||||||
Compositional bias | 235-289 | Polar residues | ||||
Sequence: SSSEDENQPPTTASRPSNGEGESQPPTAAPRTSRSVDTGSGSDASTEQQAGGQKV | ||||||
Sequence conflict | 892 | in Ref. 1; AAZ38166 | ||||
Sequence: M → V | ||||||
Sequence conflict | 911 | in Ref. 1; AAZ38166 | ||||
Sequence: T → A | ||||||
Compositional bias | 937-964 | Basic and acidic residues | ||||
Sequence: EESDAYKHTLDFDAVSPRKNKNKENRIS | ||||||
Compositional bias | 965-984 | Polar residues | ||||
Sequence: APLKQSDTLIEESTSKTSEL |
Keywords
- Coding sequence diversity
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DQ096566 EMBL· GenBank· DDBJ | AAZ38166.1 EMBL· GenBank· DDBJ | mRNA | ||
AY223804 EMBL· GenBank· DDBJ | AAP06935.1 EMBL· GenBank· DDBJ | mRNA | ||
AY223805 EMBL· GenBank· DDBJ | AAP06936.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U13771 EMBL· GenBank· DDBJ | AAC13772.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. | |
U13771 EMBL· GenBank· DDBJ | AAC13773.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. |