B6KJ32 · RON4_TOXGO

  • Protein
    Rhoptry neck protein 4
  • Gene
    RON4
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Cellular Componentsymbiont-containing vacuole membrane

Names & Taxonomy

Protein names

  • Recommended name
    Rhoptry neck protein 4
  • Alternative names
    • Tg65

Gene names

    • Name
      RON4

Organism names

  • Taxonomic identifier
  • Strain
    • RH
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Conoidasida > Coccidia > Eucoccidiorida > Eimeriorina > Sarcocystidae > Toxoplasma

Accessions

  • Primary accession
    B6KJ32
  • Secondary accessions
    • B9PI02
    • B9Q636
    • Q27914
    • Q45WA5
    • Q6XNE6

Organism-specific databases

Subcellular Location

Secreted
Note: Located prominently at the junction of the body and neck portion of the rhoptry organelle in tachyzoites and bradyzoites. Upon infection, associates with the parasitophorous vacuolar membrane (PVM).

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation.

TypeIDPosition(s)Description
Signal1-26
ChainPRO_000039881427-984Rhoptry neck protein 4
Glycosylation81N-linked (GlcNAc...) asparagine
Glycosylation390N-linked (GlcNAc...) asparagine
Glycosylation780N-linked (GlcNAc...) asparagine
Glycosylation925N-linked (GlcNAc...) asparagine

Keywords

PTM databases

Family & Domains

Features

Showing features for region, compositional bias, repeat.

TypeIDPosition(s)Description
Region24-300Disordered
Compositional bias64-107Polar residues
Repeat129-1721
Compositional bias133-160Polar residues
Compositional bias183-207Polar residues
Compositional bias235-289Polar residues
Repeat258-3012
Region882-984Disordered
Compositional bias937-964Basic and acidic residues
Compositional bias965-984Polar residues

Keywords

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 2 isoforms produced by Alternative splicing.

B6KJ32-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    984
  • Mass (Da)
    107,238
  • Last updated
    2014-04-16 v2
  • Checksum
    1CD7AD28A68789F4
MAIKNTLTGSGLLVLLTLACGTTVQSSPPTPAPRMYPNMNERPLSAESRLTPGTYRSELHIDLKSPQKTASQSSLAPTGDNNSKVESIIAGSDTTPRSAEGTSESPPVPQLGTPPRPAPRRSKGEGERQPPTAAPRTSRSVDTGSGSDASTEQQAGGQKVVTPIPASKGIYPSLDELRRSQESNVDAGSGTSTNEGGGTSEGPQVPQSGIPPRTGRRRAKARNRKRHPTPASRESSSEDENQPPTTASRPSNGEGESQPPTAAPRTSRSVDTGSGSDASTEQQAGGQKVVTPIPASKGIYPNLDELRQTQEGEESAPQPADVTWFSMSVPMGVVDRRVSRALKEQFFQFLQHLSADYPKQVQTVYEFLGWVADKLPENEEEVQMFIDALNTTEAMVGKAARWIFKAIPERERETIYSSFYQMFRDKLPKKFFETAEGMNPDVGQYFSAEEPVAVTPEIPAKSEEDSEAAETPTPLRRQANVAAQVLHPLPAKGVTRREWIPWPKMQNAISKAHGPLTRVPEWTPVTGSCALGDGYTDIDVTKATTDVLFRITLLILQQIRRKKTERGKLEDDQALVALCSAAGAFVDAWQHQQQALILEDPGTPKAHAQLIERLRNAGKYFMKSYDETTGESDHQQWKKNKAEVSKLGKSALMKSCVKYIKASGDVATRPFDSGTAKYPSRSLYGGIANTLETPFADSEAVAKAVHDYAKEHKKPEKLVGLCGALQISGYFKKCFSDAGRLSSVSFFHQHVDGASVLVRTLARERPIGRHALSQAICDPNISAQYFEGAFRLFSSTVSQEWEKENLFAQLASWTGKEMVLAPSLEEQAAVPPAQPAYETVYGDEEDRIYRIHVSGRHSSPQEVLYVGGIPSTVKPQQVHVLGPTVSDESRRMIHPVRHRSRTAPSSEAASTAAESSDEDPLPAENATAFLGVTPQEEESDAYKHTLDFDAVSPRKNKNKENRISAPLKQSDTLIEESTSKTSEL

B6KJ32-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Sequence caution

The sequence AAC13772.1 differs from that shown. Reason: Miscellaneous discrepancy Chimeric cDNA, matches the C-terminus.
The sequence AAC13773.1 differs from that shown. Reason: Miscellaneous discrepancy Chimeric cDNA, matches the C-terminus.

Features

Showing features for alternative sequence, compositional bias, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0398091-394in isoform 2
Compositional bias64-107Polar residues
Compositional bias133-160Polar residues
Compositional bias183-207Polar residues
Compositional bias235-289Polar residues
Sequence conflict892in Ref. 1; AAZ38166
Sequence conflict911in Ref. 1; AAZ38166
Compositional bias937-964Basic and acidic residues
Compositional bias965-984Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ096566
EMBL· GenBank· DDBJ
AAZ38166.1
EMBL· GenBank· DDBJ
mRNA
AY223804
EMBL· GenBank· DDBJ
AAP06935.1
EMBL· GenBank· DDBJ
mRNA
AY223805
EMBL· GenBank· DDBJ
AAP06936.1
EMBL· GenBank· DDBJ
Genomic DNA
U13771
EMBL· GenBank· DDBJ
AAC13772.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
U13771
EMBL· GenBank· DDBJ
AAC13773.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.

Similar Proteins

Disclaimer

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