B6KAS6 · DCXH_TOXGV

Function

function

Specifically required in the formation and maintenance of the conoid fibers; the conoid is a component of the cytoskeletal apical complex, which is composed of a left-handed spiral of 14 fibers made from a nontubular tubulin polymer (PubMed:27932494).
Promotes the organization, curvature, and stability of the conoid fibers, and probably bridges other conoid components to the tubulin core (PubMed:27932494, PubMed:32111164).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytoskeleton
Molecular Functiontubulin binding
Biological Processintracellular signal transduction
Biological Processmicrotubule polymerization

Names & Taxonomy

Protein names

  • Recommended name
    Doublecortin domain-containing protein
  • Short names
    TgDCX

Gene names

    • Name
      DCX
    • ORF names
      BN1205_078130
      , TGVEG_256030

Organism names

Accessions

  • Primary accession
    B6KAS6
  • Secondary accessions
    • A0A0F7UX87
    • B9QC02
    • S7WFE6
    • S8F0J1

Proteomes

    • Identifier
    • Component
      Partially assembled WGS sequence

Organism-specific databases

Subcellular Location

Note: Localizes along the tubulin-containing conoid fibers; the conoid is a component of the cytoskeletal apical complex, which is composed of a left-handed spiral of 14 fibers made from a nontubular tubulin polymer (PubMed:27932494, PubMed:32111164).
During early daughter development, localizes to the center of a five-petaled flower-like tubulin structure in the nascent daughter apical cytoskeleton (PubMed:27932494).

Keywords

Phenotypes & Variants

Disruption phenotype

Reduced tachyzoite growth and host invasion (PubMed:27932494).
Loss of tubulin at the apical complex (PubMed:27932494).
Abnormal conoid morphology characterized by a shorter and less rectangular structure a weaker or absent basket-weave stripe pattern (PubMed:27932494).
Cortical microtubules, the mitotic spindle, spindle pole, and centrioles are normal (PubMed:27932494).

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004551121-256Doublecortin domain-containing protein

Proteomic databases

Expression

Developmental stage

Expressed in tachyzoites (at protein level).

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region71-103Partial p25alpha domain
Domain152-226Doublecortin

Domain

The doublecortin is involved in the binding to microtubules; however, it is not sufficient by itself and requires the partial p25alpha domain.
The partial p25 alpha domain binds to microtubules.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    256
  • Mass (Da)
    29,222
  • Last updated
    2008-12-16 v1
  • MD5 Checksum
    19265B3B019BD4EF667F9B7D40115AF5
MACGIPWKLARRDELMATRQAERPGEYFPPPYPPCPPTVVTPLRTSAYDFPEATFVTRPCLPAKKATGHKNVFERLTDTAYYTGSHRERFDEFGNGRGIAGREYLYAYDGLTESPSRCHEVYSSVIKRPRKPVVTPGTLGIQRFGVQIPAPRLMWLYRNGDKHDDGTPFFVRPYIKSMESLYQQITKEITPIAGPVRRIFDQNFRVITDLDDIVDGAKYLCTSGEPPAAYDRLEKFLSEWVIQKSQTKVPSQFFVV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LN714497
EMBL· GenBank· DDBJ
CEL74611.1
EMBL· GenBank· DDBJ
Genomic DNA
AAYL02000031
EMBL· GenBank· DDBJ
ESS35450.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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