B6KAS6 · DCXH_TOXGV
- ProteinDoublecortin domain-containing protein
- GeneDCX
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids256 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Specifically required in the formation and maintenance of the conoid fibers; the conoid is a component of the cytoskeletal apical complex, which is composed of a left-handed spiral of 14 fibers made from a nontubular tubulin polymer (PubMed:27932494).
Promotes the organization, curvature, and stability of the conoid fibers, and probably bridges other conoid components to the tubulin core (PubMed:27932494, PubMed:32111164).
Promotes the organization, curvature, and stability of the conoid fibers, and probably bridges other conoid components to the tubulin core (PubMed:27932494, PubMed:32111164).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytoskeleton | |
Molecular Function | tubulin binding | |
Biological Process | intracellular signal transduction | |
Biological Process | microtubule polymerization |
Names & Taxonomy
Protein names
- Recommended nameDoublecortin domain-containing protein
- Short namesTgDCX
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Conoidasida > Coccidia > Eucoccidiorida > Eimeriorina > Sarcocystidae > Toxoplasma
Accessions
- Primary accessionB6KAS6
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Localizes along the tubulin-containing conoid fibers; the conoid is a component of the cytoskeletal apical complex, which is composed of a left-handed spiral of 14 fibers made from a nontubular tubulin polymer (PubMed:27932494, PubMed:32111164).
During early daughter development, localizes to the center of a five-petaled flower-like tubulin structure in the nascent daughter apical cytoskeleton (PubMed:27932494).
During early daughter development, localizes to the center of a five-petaled flower-like tubulin structure in the nascent daughter apical cytoskeleton (PubMed:27932494).
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Reduced tachyzoite growth and host invasion (PubMed:27932494).
Loss of tubulin at the apical complex (PubMed:27932494).
Abnormal conoid morphology characterized by a shorter and less rectangular structure a weaker or absent basket-weave stripe pattern (PubMed:27932494).
Cortical microtubules, the mitotic spindle, spindle pole, and centrioles are normal (PubMed:27932494).
Loss of tubulin at the apical complex (PubMed:27932494).
Abnormal conoid morphology characterized by a shorter and less rectangular structure a weaker or absent basket-weave stripe pattern (PubMed:27932494).
Cortical microtubules, the mitotic spindle, spindle pole, and centrioles are normal (PubMed:27932494).
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000455112 | 1-256 | Doublecortin domain-containing protein | ||
Proteomic databases
Expression
Developmental stage
Expressed in tachyzoites (at protein level).
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 71-103 | Partial p25alpha domain | |||
Domain | 152-226 | Doublecortin | |||
Domain
The doublecortin is involved in the binding to microtubules; however, it is not sufficient by itself and requires the partial p25alpha domain.
The partial p25 alpha domain binds to microtubules.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length256
- Mass (Da)29,222
- Last updated2008-12-16 v1
- MD5 Checksum19265B3B019BD4EF667F9B7D40115AF5
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
LN714497 EMBL· GenBank· DDBJ | CEL74611.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAYL02000031 EMBL· GenBank· DDBJ | ESS35450.1 EMBL· GenBank· DDBJ | Genomic DNA |