B6H3B2 · VEA_PENRW
- ProteinDevelopmental and secondary metabolism regulator veA
- GenevelA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids561 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination (PubMed:20543063).
The velvet complex acts as a global regulator for secondary metabolite gene expression (PubMed:22439693).
Controls the expression of the penicillin gene cluster (PubMed:20543063, PubMed:22439693).
Positively controls the expression of the class V chitinase chiB1 (PubMed:21816879).
Positively controls the expression of the transcription factor atfA (PubMed:25557366).
Required for cell wall integrity and controls hyphal branching (PubMed:20543063).
The velvet complex acts as a global regulator for secondary metabolite gene expression (PubMed:22439693).
Controls the expression of the penicillin gene cluster (PubMed:20543063, PubMed:22439693).
Positively controls the expression of the class V chitinase chiB1 (PubMed:21816879).
Positively controls the expression of the transcription factor atfA (PubMed:25557366).
Required for cell wall integrity and controls hyphal branching (PubMed:20543063).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Biological Process | sporulation resulting in formation of a cellular spore |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDevelopmental and secondary metabolism regulator veA
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Penicillium > Penicillium chrysogenum species complex
Accessions
- Primary accessionB6H3B2
Proteomes
Organism-specific databases
Phenotypes & Variants
Disruption phenotype
Substantially down-regulates penicillin biosynthesis genes pcbAB, pcbC, and penDE (PubMed:20543063).
Up-regulates expression of laeA (PubMed:20543063).
Leads to light-independent conidial formation, dichotomous branching of hyphae, and pellet formation in shaking cultures (PubMed:20543063).
Decreases the expression of the class V chitinase chiB1 (PubMed:21816879).
Decreases the expression of the transcription factor atfA (PubMed:25557366).
Up-regulates expression of laeA (PubMed:20543063).
Leads to light-independent conidial formation, dichotomous branching of hyphae, and pellet formation in shaking cultures (PubMed:20543063).
Decreases the expression of the class V chitinase chiB1 (PubMed:21816879).
Decreases the expression of the transcription factor atfA (PubMed:25557366).
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000435906 | 1-561 | Developmental and secondary metabolism regulator veA | ||
Structure
Family & Domains
Features
Showing features for region, domain, motif, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-23 | Disordered | |||
Domain | 25-233 | Velvet | |||
Motif | 39-44 | Nuclear localization signal | |||
Region | 41-60 | Disordered | |||
Region | 258-361 | Disordered | |||
Compositional bias | 325-340 | Polar residues | |||
Compositional bias | 344-360 | Pro residues | |||
Region | 438-485 | PEST | |||
Region | 491-524 | Disordered | |||
Domain
The C-terminal PEST domain is a region rich in proline, glutamic acid, serine and threonine residues that is required for the light-dependent regulation of development and secondary metabolism (By similarity).
Sequence similarities
Belongs to the velvet family. VeA subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length561
- Mass (Da)61,987
- Last updated2008-12-16 v1
- Checksum45B666DE9B05B943
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 325-340 | Polar residues | |||
Compositional bias | 344-360 | Pro residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AM920428 EMBL· GenBank· DDBJ | CAP92389.1 EMBL· GenBank· DDBJ | Genomic DNA |