B6F0Z6 · B6F0Z6_ACISC

Function

function

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular Functionestrogen response element binding
Molecular Functionhormone binding
Molecular Functionnuclear estrogen receptor activity
Molecular Functionnuclear receptor activity
Molecular Functionsteroid binding
Molecular Functionzinc ion binding
Biological Processcellular response to estrogen stimulus
Biological Processestrogen receptor signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Estrogen receptor
  • Alternative names
    • ER-alpha
    • Estradiol receptor
    • Nuclear receptor subfamily 3 group A member 1

Gene names

    • Name
      ESR1a

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Chondrostei > Acipenseriformes > Acipenseridae > Acipenser

Accessions

  • Primary accession
    B6F0Z6

Subcellular Location

Keywords

  • Cellular component

Interaction

Subunit

Binds DNA as a homodimer. Can form a heterodimer with ER-beta.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain144-219Nuclear receptor
Domain270-506NR LBD

Sequence similarities

Belongs to the nuclear hormone receptor family. NR3 subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    523
  • Mass (Da)
    59,464
  • Last updated
    2008-12-16 v1
  • Checksum
    0C959B0E47FA0BB0
MYLEENRTSATVNYLDNTYEFAAAAAAPLYNPSNLVYHSAPLEPHSSASEGNLHSRGNVPTSPLVFMPSNPQLSSFIHHHHHHSRQIPYYLENDQGSYRLREATPEPIFRPSMEGRYQGVREQLSDMGQKGSPSSGPSKLSKEMRFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCNEVGMMKGGVRKDRRGRHMLKVKRTASEQDEKSHVNGHDRRLTLTLEPTPINNGKKNSALGLSIDQVLIHLLEAEPPTQYSKQNQNRPYTEISMMNILTSLADKELVHMIAWAKKIPGFVDLSLHDQVQLLECSWLEVLMIGLIWRSVEFPGKLIFAPDLSFDRNEGSCVEGMVEIFDMLLTTSRRFFTLKLKNEEYMCLKAIILLNSGAFPFLSSSMETLNDSQTIQLLLDKITDTLIHVIAKSGLPPQQQSRRQAQLLLLLSHIRHMSIKGMEHLYNMKCKNIVPPYDLLLEMLDAHRLHCPGDSEPEKRQVDK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB435631
EMBL· GenBank· DDBJ
BAG82650.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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