B6E301 · B6E301_9COLE

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • HAGLAA
    • HAGLAB
    • HAGLAC
    • HAGLAD
    • HAGLAE
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Elateriformia > Elateroidea > Cantharidae > Cantharinae > Hatchiana

Accessions

  • Primary accession
    B6E301
  • Secondary accessions
    • B6UPK4
    • B7TIY4

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane46-67Helical
Transmembrane88-110Helical
Transmembrane130-155Helical
Transmembrane167-194Helical

Keywords

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-219Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    219
  • Mass (Da)
    23,718
  • Last updated
    2009-03-24 v2
  • Checksum
    10D9D2D3CB4D4482
TLYFIFGAWSGSLGLALSLLIRAELGTPGTLIGNDQLYNVIVTAHAFIMIFFMVMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWFLPPSLMFLLMSSMVESGAGTGWTVYPPLSANIAHSGPSVDLAIFSLHMAGISSILGAVNFISTIMNMKPPSMKFDQMPLFVWSVGITALLLLLSLPVLAGAITMLLSDRNLNTSFFDPMGGGDPILYQHLF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue219

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FJ174665
EMBL· GenBank· DDBJ
ACJ11216.2
EMBL· GenBank· DDBJ
Genomic DNA
FJ232991
EMBL· GenBank· DDBJ
ACJ54126.2
EMBL· GenBank· DDBJ
Genomic DNA
FJ605142
EMBL· GenBank· DDBJ
ACM46034.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ605143
EMBL· GenBank· DDBJ
ACM46035.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ605144
EMBL· GenBank· DDBJ
ACM46036.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ605145
EMBL· GenBank· DDBJ
ACM46037.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ605146
EMBL· GenBank· DDBJ
ACM46038.1
EMBL· GenBank· DDBJ
Genomic DNA
GU323924
EMBL· GenBank· DDBJ
ADC36167.1
EMBL· GenBank· DDBJ
Genomic DNA
GU323925
EMBL· GenBank· DDBJ
ADC36168.1
EMBL· GenBank· DDBJ
Genomic DNA
GU323926
EMBL· GenBank· DDBJ
ADC36169.1
EMBL· GenBank· DDBJ
Genomic DNA
GU323927
EMBL· GenBank· DDBJ
ADC36170.1
EMBL· GenBank· DDBJ
Genomic DNA
GU323928
EMBL· GenBank· DDBJ
ADC36171.1
EMBL· GenBank· DDBJ
Genomic DNA
GU323930
EMBL· GenBank· DDBJ
ADC36173.1
EMBL· GenBank· DDBJ
Genomic DNA
GU323931
EMBL· GenBank· DDBJ
ADC36174.1
EMBL· GenBank· DDBJ
Genomic DNA
GU323932
EMBL· GenBank· DDBJ
ADC36175.1
EMBL· GenBank· DDBJ
Genomic DNA
GU323933
EMBL· GenBank· DDBJ
ADC36176.1
EMBL· GenBank· DDBJ
Genomic DNA
GU323934
EMBL· GenBank· DDBJ
ADC36177.1
EMBL· GenBank· DDBJ
Genomic DNA
GU323935
EMBL· GenBank· DDBJ
ADC36178.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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