B6CTZ0 · B6CTZ0_URSAR
- ProteinNADH-ubiquinone oxidoreductase chain 6
- GeneND6
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids175 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Catalytic activity
- a ubiquinone + 5 H+(in) + NADH = a ubiquinol + 4 H+(out) + NAD+
a ubiquinone RHEA-COMP:9565 + 5 H+ (in)CHEBI:15378+ CHEBI:57945 = a ubiquinol RHEA-COMP:9566 + 4 H+ (out)CHEBI:15378+ CHEBI:57540
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respirasome | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-ubiquinone oxidoreductase chain 6
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Ursidae > Ursus
Accessions
- Primary accessionB6CTZ0
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Mitochondrion membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 26-47 | Helical | ||||
Sequence: PIYGGLVLIISGGVGCGIVLSF | ||||||
Transmembrane | 54-76 | Helical | ||||
Sequence: LMVFLIYLGGMLVVFGYTTAMAT | ||||||
Transmembrane | 88-108 | Helical | ||||
Sequence: AVLGAFIVGLLSELLIACYVL | ||||||
Transmembrane | 146-169 | Helical | ||||
Sequence: LYSYGTWLVIVTGWSLLIGVLVIM |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-16 | |||||
Sequence: MMMYIVFILSVVFVMG | ||||||
Chain | PRO_5008411216 | 17-175 | NADH-ubiquinone oxidoreductase chain 6 | |||
Sequence: FVGFSSKPSPIYGGLVLIISGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEQYPEVWISNKAVLGAFIVGLLSELLIACYVLKDDEVEIVFKFNGMGDWVIYDTGDSGFFSEEAMGIAALYSYGTWLVIVTGWSLLIGVLVIMEVTRGN |
Interaction
Subunit
Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
Structure
Sequence
- Sequence statusComplete
- Length175
- Mass (Da)18,890
- Last updated2008-11-25 v1
- ChecksumAF568A2D0DAADB71
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
EU497665 EMBL· GenBank· DDBJ | ACA24722.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX641317 EMBL· GenBank· DDBJ | AOD42296.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX641318 EMBL· GenBank· DDBJ | AOD42309.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX641319 EMBL· GenBank· DDBJ | AOD42322.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX641320 EMBL· GenBank· DDBJ | AOD42335.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX641321 EMBL· GenBank· DDBJ | AOD42348.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX641322 EMBL· GenBank· DDBJ | AOD42361.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX641323 EMBL· GenBank· DDBJ | AOD42374.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX641324 EMBL· GenBank· DDBJ | AOD42387.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX641325 EMBL· GenBank· DDBJ | AOD42400.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX641326 EMBL· GenBank· DDBJ | AOD42413.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX641327 EMBL· GenBank· DDBJ | AOD42426.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX641328 EMBL· GenBank· DDBJ | AOD42439.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX641329 EMBL· GenBank· DDBJ | AOD42452.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX641336 EMBL· GenBank· DDBJ | AOD42541.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF593957 EMBL· GenBank· DDBJ | ATP84502.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF593964 EMBL· GenBank· DDBJ | ATP84593.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF593965 EMBL· GenBank· DDBJ | ATP84606.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF593966 EMBL· GenBank· DDBJ | ATP84619.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF593967 EMBL· GenBank· DDBJ | ATP84632.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF593968 EMBL· GenBank· DDBJ | ATP84645.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF593969 EMBL· GenBank· DDBJ | ATP84658.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF593970 EMBL· GenBank· DDBJ | ATP84671.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF593971 EMBL· GenBank· DDBJ | ATP84684.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF593972 EMBL· GenBank· DDBJ | ATP84697.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF593973 EMBL· GenBank· DDBJ | ATP84710.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF593974 EMBL· GenBank· DDBJ | ATP84723.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF593975 EMBL· GenBank· DDBJ | ATP84736.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF593978 EMBL· GenBank· DDBJ | ATP84774.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF593979 EMBL· GenBank· DDBJ | ATP84788.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY419697 EMBL· GenBank· DDBJ | ATW74602.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP012591 EMBL· GenBank· DDBJ | BAN58046.1 EMBL· GenBank· DDBJ | Genomic DNA |