B6CMH4 · B6CMH4_URSSP
- ProteinCytochrome c oxidase subunit 1
- GeneCOX1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids514 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2O
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Cofactor
Protein has several cofactor binding sites:
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Ursidae > Ursus
Accessions
- Primary accessionB6CMH4
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 58-83 | Helical | ||||
Sequence: VTAHAFVMIFFMVMPIMIGGFGNWLV | ||||||
Transmembrane | 104-128 | Helical | ||||
Sequence: LLPPSFLLLLASSMVEAGAGTGWTV | ||||||
Transmembrane | 148-171 | Helical | ||||
Sequence: FSLHLAGISSILGAINFITTIINM | ||||||
Transmembrane | 183-210 | Helical | ||||
Sequence: LFVWSVLITAVLLLLSLPVLAAGITMLL | ||||||
Transmembrane | 243-261 | Helical | ||||
Sequence: VYILILPGFGMISHIVTYY | ||||||
Transmembrane | 268-291 | Helical | ||||
Sequence: FGYMGMVWAMVSIGFLGFIVWAHH | ||||||
Transmembrane | 303-325 | Helical | ||||
Sequence: AYFTSATMIIAIPTGVKVFSWLA | ||||||
Transmembrane | 337-359 | Helical | ||||
Sequence: AMMWALGFIFLFTVGGLTGIVLA | ||||||
Transmembrane | 379-400 | Helical | ||||
Sequence: YVLSMGAVFAIMGGFVHWFPLF | ||||||
Transmembrane | 412-430 | Helical | ||||
Sequence: IHFMIMFIGVNMTFFPQHF | ||||||
Transmembrane | 450-473 | Helical | ||||
Sequence: WNTVSSVGSFISLTAVMLMIFMIW |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-514 | Cytochrome oxidase subunit I profile | ||||
Sequence: MFMNRWLFSTNHKDIGTLYLLFGAWAGMVGTALSLLIRAELGQPGALLGDDQIYNVVVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGISSILGAINFITTIINMKPPAMSQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMVSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMMWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLFSGYTLNNTWAKIHFMIMFIGVNMTFFPQHFLGLSGMPRRYSDYPDAYTTWNTVSSVGSFISLTAVMLMIFMIWEAFASKREVAVVELTSTNIEWLHGCPPPYHTFEEPAYVMLK |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length514
- Mass (Da)56,979
- Last updated2008-11-25 v1
- Checksum1322A5B2F5F1929B
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
EU327344 EMBL· GenBank· DDBJ | ABX82893.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX641291 EMBL· GenBank· DDBJ | AOD41949.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX641305 EMBL· GenBank· DDBJ | AOD42131.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX641307 EMBL· GenBank· DDBJ | AOD42157.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX641311 EMBL· GenBank· DDBJ | AOD42209.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX641312 EMBL· GenBank· DDBJ | AOD42222.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX641314 EMBL· GenBank· DDBJ | AOD42248.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX641334 EMBL· GenBank· DDBJ | AOD42506.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX641337 EMBL· GenBank· DDBJ | AOD42545.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN390847 EMBL· GenBank· DDBJ | CAY40014.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN390849 EMBL· GenBank· DDBJ | CAY40065.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN390852 EMBL· GenBank· DDBJ | CAY40145.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN390867 EMBL· GenBank· DDBJ | CAY40544.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN390868 EMBL· GenBank· DDBJ | CAY40570.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN390872 EMBL· GenBank· DDBJ | CAY40676.1 EMBL· GenBank· DDBJ | Genomic DNA |