B6CMH4 · B6CMH4_URSSP

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COX1
    • Synonyms
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • SP1325
    • SP1497
    • SP2085
    • SP2091
    • SP2133
    • SP370
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Ursidae > Ursus

Accessions

  • Primary accession
    B6CMH4

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane58-83Helical
Transmembrane104-128Helical
Transmembrane148-171Helical
Transmembrane183-210Helical
Transmembrane243-261Helical
Transmembrane268-291Helical
Transmembrane303-325Helical
Transmembrane337-359Helical
Transmembrane379-400Helical
Transmembrane412-430Helical
Transmembrane450-473Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-514Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    514
  • Mass (Da)
    56,979
  • Last updated
    2008-11-25 v1
  • Checksum
    1322A5B2F5F1929B
MFMNRWLFSTNHKDIGTLYLLFGAWAGMVGTALSLLIRAELGQPGALLGDDQIYNVVVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGISSILGAINFITTIINMKPPAMSQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMVSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMMWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLFSGYTLNNTWAKIHFMIMFIGVNMTFFPQHFLGLSGMPRRYSDYPDAYTTWNTVSSVGSFISLTAVMLMIFMIWEAFASKREVAVVELTSTNIEWLHGCPPPYHTFEEPAYVMLK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EU327344
EMBL· GenBank· DDBJ
ABX82893.1
EMBL· GenBank· DDBJ
Genomic DNA
KX641291
EMBL· GenBank· DDBJ
AOD41949.1
EMBL· GenBank· DDBJ
Genomic DNA
KX641305
EMBL· GenBank· DDBJ
AOD42131.1
EMBL· GenBank· DDBJ
Genomic DNA
KX641307
EMBL· GenBank· DDBJ
AOD42157.1
EMBL· GenBank· DDBJ
Genomic DNA
KX641311
EMBL· GenBank· DDBJ
AOD42209.1
EMBL· GenBank· DDBJ
Genomic DNA
KX641312
EMBL· GenBank· DDBJ
AOD42222.1
EMBL· GenBank· DDBJ
Genomic DNA
KX641314
EMBL· GenBank· DDBJ
AOD42248.1
EMBL· GenBank· DDBJ
Genomic DNA
KX641334
EMBL· GenBank· DDBJ
AOD42506.1
EMBL· GenBank· DDBJ
Genomic DNA
KX641337
EMBL· GenBank· DDBJ
AOD42545.1
EMBL· GenBank· DDBJ
Genomic DNA
FN390847
EMBL· GenBank· DDBJ
CAY40014.1
EMBL· GenBank· DDBJ
Genomic DNA
FN390849
EMBL· GenBank· DDBJ
CAY40065.1
EMBL· GenBank· DDBJ
Genomic DNA
FN390852
EMBL· GenBank· DDBJ
CAY40145.1
EMBL· GenBank· DDBJ
Genomic DNA
FN390867
EMBL· GenBank· DDBJ
CAY40544.1
EMBL· GenBank· DDBJ
Genomic DNA
FN390868
EMBL· GenBank· DDBJ
CAY40570.1
EMBL· GenBank· DDBJ
Genomic DNA
FN390872
EMBL· GenBank· DDBJ
CAY40676.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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