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B6BEP9 · B6BEP9_9RHOB

Function

function

Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi. To a lesser extent, also acts on hypoxanthine.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Purine metabolism; GMP biosynthesis via salvage pathway; GMP from guanine: step 1/1.
Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site47-485-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site102-1105-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site103Mg2+ (UniProtKB | ChEBI)
Binding site106guanine (UniProtKB | ChEBI)
Binding site106xanthine (UniProtKB | ChEBI)
Binding site106-110GMP (UniProtKB | ChEBI)
Binding site148-149GMP (UniProtKB | ChEBI)
Binding site149guanine (UniProtKB | ChEBI)
Binding site149xanthine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionguanine phosphoribosyltransferase activity
Molecular Functionhypoxanthine phosphoribosyltransferase activity
Molecular Functionmagnesium ion binding
Molecular Functionxanthine phosphoribosyltransferase activity
Biological ProcessGMP salvage
Biological Processpurine ribonucleoside salvage
Biological ProcessXMP salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Xanthine-guanine phosphoribosyltransferase
  • EC number
  • Short names
    XGPRT
  • Alternative names
    • Xanthine phosphoribosyltransferase

Gene names

    • Name
      gpt
    • ORF names
      RBY4I_1827

Organism names

Accessions

  • Primary accession
    B6BEP9

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein

Keywords

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain14-159Phosphoribosyltransferase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    167
  • Mass (Da)
    18,854
  • Last updated
    2008-11-25 v1
  • MD5 Checksum
    4B956B2F5068D28FB2409F61D1623C69
MTDRLPHEKGFHISWDQIHRDSRALAWRLDGQGPDSGAWRAVVAITRGGMAPAMIVSRELDIRTVDTISVRSYHHQAQGEAEVLKAPDVSLMGDGEGVLIIDDLVDSGKTLELVREMYPKAHFATVYAKPKGRPMVDTFITEVSQDTWIFFPWDMALQYVEPYRGKD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS995281
EMBL· GenBank· DDBJ
EDZ46611.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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