B5Z8M0 · FLUC_HELPG

Function

function

Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.

Catalytic activity

Activity regulation

Na+ is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

Features

Showing features for binding site.

1130102030405060708090100110120130
TypeIDPosition(s)Description
Binding site77Na+ (UniProtKB | ChEBI); structural
Binding site80Na+ (UniProtKB | ChEBI); structural

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionfluoride channel activity
Molecular Functionmetal ion binding
Biological Processcellular detoxification of fluoride

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Fluoride-specific ion channel FluC

Gene names

    • Name
      fluC
    • Synonyms
      crcB
    • Ordered locus names
      HPG27_1169

Organism names

Accessions

  • Primary accession
    B5Z8M0

Proteomes

Subcellular Location

Cell inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane3-23Helical
Transmembrane38-58Helical
Transmembrane67-87Helical
Transmembrane102-122Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001251351-130Fluoride-specific ion channel FluC

Structure

Family & Domains

Sequence similarities

Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    130
  • Mass (Da)
    14,135
  • Last updated
    2008-11-25 v1
  • Checksum
    ACB236AAECBDC977
MNFVFLWAALGGAIGSSLRYFVGKMMPSKFLMFESFPLGTFSVNIIGCFVIGFMGHLATKKVFGDDFGIFFVTGVLGGFTTFSSYGLDTLKLLQKSQYIEAISYVLGTNLLGLIGVAIGWFLAKNFVGVH

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001173
EMBL· GenBank· DDBJ
ACI27919.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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