B5Z6N2 · DAPB_HELPG
- Protein4-hydroxy-tetrahydrodipicolinate reductase
- GenedapB
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids254 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
Catalytic activity
- (S)-2,3,4,5-tetrahydrodipicolinate + NAD+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H+
Pathway
Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 7-12 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: GASGRI | ||||||
Binding site | 35 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 91-93 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: GTT | ||||||
Binding site | 115-118 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: AHNM | ||||||
Active site | 147 | Proton donor/acceptor | ||||
Sequence: H | ||||||
Binding site | 148 | (S)-2,3,4,5-tetrahydrodipicolinate (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Active site | 151 | Proton donor | ||||
Sequence: K | ||||||
Binding site | 157-158 | (S)-2,3,4,5-tetrahydrodipicolinate (UniProtKB | ChEBI) | ||||
Sequence: GT |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 4-hydroxy-tetrahydrodipicolinate reductase | |
Molecular Function | NAD binding | |
Molecular Function | NADP binding | |
Molecular Function | oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor | |
Biological Process | diaminopimelate biosynthetic process | |
Biological Process | lysine biosynthetic process via diaminopimelate |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4-hydroxy-tetrahydrodipicolinate reductase
- EC number
- Short namesHTPA reductase
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Campylobacterota > Epsilonproteobacteria > Campylobacterales > Helicobacteraceae > Helicobacter
Accessions
- Primary accessionB5Z6N2
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000093975 | 1-254 | 4-hydroxy-tetrahydrodipicolinate reductase | |||
Sequence: MKIGVYGASGRIGKLLLEELKGGYKGLELSSVFVRQKCETDFSSFSHAPLVTNDLKAFVRACECVIDFSLPKGVDHLLEALLECPKILVSGTTGLEKETLEKMQKLALKAPLLHAHNMSIGIMMLNQLAFLASLKLKDADIEIIETHHNLKKDAPSGTALSLYETCAKARGYDEKNALTTHREGLRSKESIGIAALRGGDVAGKHTIGFYLEGEYIELSHTATNRSIFAKGALEVALWLKDKAAKKYEINEMFG |
Structure
Sequence
- Sequence statusComplete
- Length254
- Mass (Da)27,824
- Last updated2008-11-25 v1
- Checksum54B190DFA0E3579A
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001173 EMBL· GenBank· DDBJ | ACI27231.1 EMBL· GenBank· DDBJ | Genomic DNA |