B5Z6N2 · DAPB_HELPG

Function

function

Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.

Caution

Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site7-12NAD+ (UniProtKB | ChEBI)
Binding site35NADP+ (UniProtKB | ChEBI)
Binding site91-93NAD+ (UniProtKB | ChEBI)
Binding site115-118NAD+ (UniProtKB | ChEBI)
Active site147Proton donor/acceptor
Binding site148(S)-2,3,4,5-tetrahydrodipicolinate (UniProtKB | ChEBI)
Active site151Proton donor
Binding site157-158(S)-2,3,4,5-tetrahydrodipicolinate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function4-hydroxy-tetrahydrodipicolinate reductase
Molecular FunctionNAD binding
Molecular FunctionNADP binding
Molecular Functionoxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
Biological Processdiaminopimelate biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-hydroxy-tetrahydrodipicolinate reductase
  • EC number
  • Short names
    HTPA reductase

Gene names

    • Name
      dapB
    • Ordered locus names
      HPG27_468

Organism names

Accessions

  • Primary accession
    B5Z6N2

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000939751-2544-hydroxy-tetrahydrodipicolinate reductase

Structure

Family & Domains

Sequence similarities

Belongs to the DapB family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    254
  • Mass (Da)
    27,824
  • Last updated
    2008-11-25 v1
  • Checksum
    54B190DFA0E3579A
MKIGVYGASGRIGKLLLEELKGGYKGLELSSVFVRQKCETDFSSFSHAPLVTNDLKAFVRACECVIDFSLPKGVDHLLEALLECPKILVSGTTGLEKETLEKMQKLALKAPLLHAHNMSIGIMMLNQLAFLASLKLKDADIEIIETHHNLKKDAPSGTALSLYETCAKARGYDEKNALTTHREGLRSKESIGIAALRGGDVAGKHTIGFYLEGEYIELSHTATNRSIFAKGALEVALWLKDKAAKKYEINEMFG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001173
EMBL· GenBank· DDBJ
ACI27231.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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