B5Z6I2 · PYRD_HELPG
- ProteinDihydroorotate dehydrogenase (quinone)
- GenepyrD
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids351 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
Catalytic activity
- (S)-dihydroorotate + a quinone = orotate + a quinol
Cofactor
Note: Binds 1 FMN per subunit.
Pathway
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 67-71 | FMN (UniProtKB | ChEBI) | ||||
Sequence: AGFDK | ||||||
Binding site | 71 | substrate | ||||
Sequence: K | ||||||
Binding site | 91 | FMN (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 116-120 | substrate | ||||
Sequence: NAMGF | ||||||
Binding site | 145 | FMN (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 178 | FMN (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 178 | substrate | ||||
Sequence: N | ||||||
Active site | 181 | Nucleophile | ||||
Sequence: S | ||||||
Binding site | 183 | substrate | ||||
Sequence: N | ||||||
Binding site | 214 | FMN (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 242 | FMN (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 243-244 | substrate | ||||
Sequence: NT | ||||||
Binding site | 262 | FMN (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 291 | FMN (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 312-313 | FMN (UniProtKB | ChEBI) | ||||
Sequence: YS |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | plasma membrane | |
Molecular Function | dihydroorotate dehydrogenase (quinone) activity | |
Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | |
Biological Process | 'de novo' UMP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDihydroorotate dehydrogenase (quinone)
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Campylobacterota > Epsilonproteobacteria > Campylobacterales > Helicobacteraceae > Helicobacter
Accessions
- Primary accessionB5Z6I2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000100267 | 1-351 | Dihydroorotate dehydrogenase (quinone) | |||
Sequence: MLYPLVKKYLFSLDAEDAHEKVCKILRTLSKSSFLCSLIHSQWGYKNPKLENEILGLNFPNPLGLAAGFDKNASMLRALIAFGFGYLEAGTLTNEAQVGNERPRLFRHIEEESLQNAMGFNNYGAVLGARSFNRFAPYKTPIGINLGKNKHIEQAHALEDYKAVLNQCLNIGDYYTFNLSSPNTPNLRDLQNKAFVNELFCMAKEMTHKPLFLKIAPDLEIDDMLEIVNSAIEAGAHGIIATNTTIDKSLVFAPKEMGGLSGKCLTKKSREVFKELAKAFFNKSVLVSVGGISDAKEAYERIKMGASLLQIYSAFIYNGPNLCQNILKDLVKLLQKDGFLSVKEAIGADLR |
Interaction
Subunit
Monomer.
Structure
Sequence
- Sequence statusComplete
- Length351
- Mass (Da)38,985
- Last updated2008-11-25 v1
- ChecksumD9323D5317035868
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001173 EMBL· GenBank· DDBJ | ACI27181.1 EMBL· GenBank· DDBJ | Genomic DNA |