B5Z4F4 · AAS_ECO5E

Function

function

Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1.

Catalytic activity

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site36

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionacyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity
Molecular FunctionATP binding
Molecular Functionlong-chain fatty acid [acyl-carrier-protein] ligase activity
Molecular Functionmedium-chain fatty acid-CoA ligase activity
Biological Processfatty acid metabolic process
Biological Processphospholipid biosynthetic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional protein Aas

Including 2 domains:

  • Recommended name
    2-acylglycerophosphoethanolamine acyltransferase
  • EC number
  • Alternative names
    • 2-acyl-GPE acyltransferase
    • Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase
  • Recommended name
    Acyl-[acyl-carrier-protein] synthetase
  • EC number
  • Alternative names
    • Acyl-ACP synthetase
    • Long-chain-fatty-acid--[acyl-carrier-protein] ligase

Gene names

    • Name
      aas
    • Ordered locus names
      ECH74115_4103

Organism names

Accessions

  • Primary accession
    B5Z4F4

Subcellular Location

Cell inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane258-277Helical
Transmembrane409-433Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001378861-719Bifunctional protein Aas

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region15-138Acyltransferase
Region233-646AMP-binding

Sequence similarities

In the N-terminal section; belongs to the 2-acyl-GPE acetyltransferase family.
In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    719
  • Mass (Da)
    80,764
  • Last updated
    2008-11-25 v1
  • Checksum
    786640F7D3330B7C
MLFSFFRNLCRVLYRVRVTGDPQALKGERVLITPNHVSFIDGILLGLFLPVRPVFAVYTSISQQWYMRWLKSFIDFVPLDPTQPMAIKHLVRLVEQGRPVVIFPEGRITTTGSLMKIYDGAGFVAAKSGATVIPVRIEGAELTHFSRLKGLVKRRLFPQITLHILPPTQVEMPDAPRARDRRKIAGEMLHQIMMEARMAVRPRETLYESLLSAMYRFGAGKKCVEDVNFTPDSYRKLLTKTLFVGRILEKYSVEGERIGLMLPNAGISAAVIFGAIARRRIPAMMNYTAGVKGLTSAITAAEIKTIFTSRQFLDKGKLWHLPEQLTQVRWVYLEDLKADVTTADKVWIFAHLLMPRLAQVKQQPEEEALILFTSGSEGHPKGVVHSHKSILANVEQIKTIADFTTNDRFMSALPLFHSFGLTVGLFTPLLTGAEVFLYPSPLHYRIVPELVYDRSCTVLFGTSTFLGHYARFANPYDFYRLRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINVPMAAKPGTVGRILPGMDARLLSVPGIEEGGRLQLKGPNIMNGYLRVEKPGVLEVPTAENVRGEMERGWYDTGDIVRFDEQGFVQIQGRAKRFAKIAGEMVSLEMVEQLALGVSPDKVHATAIKSDASKGEALVLFTTDNELTRDKLQQYAREHGVPELAVPRDIRYLKQMPLLGSGKPDFVTLKSWVDEVEQHDE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001164
EMBL· GenBank· DDBJ
ACI38434.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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