B5YS30 · KBAY_ECO5E
- ProteinD-tagatose-1,6-bisphosphate aldolase subunit KbaY
- GenekbaY
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids286 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalytic subunit of the tagatose-1,6-bisphosphate aldolase KbaYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP). Requires KbaZ subunit for full activity and stability.
Catalytic activity
- D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Carbohydrate metabolism; D-tagatose 6-phosphate degradation; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate: step 2/2.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 82 | Proton donor | ||||
Sequence: D | ||||||
Binding site | 83 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 180 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 181 | dihydroxyacetone phosphate (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 208 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 209-211 | dihydroxyacetone phosphate (UniProtKB | ChEBI) | ||||
Sequence: GAS | ||||||
Binding site | 230-233 | dihydroxyacetone phosphate (UniProtKB | ChEBI) | ||||
Sequence: NVAT |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | tagatose-bisphosphate aldolase activity | |
Molecular Function | zinc ion binding | |
Biological Process | carbohydrate metabolic process | |
Biological Process | D-tagatose 6-phosphate catabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameD-tagatose-1,6-bisphosphate aldolase subunit KbaY
- EC number
- Short namesTBPA ; TagBP aldolase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia
Accessions
- Primary accessionB5YS30
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000140429 | 1-286 | D-tagatose-1,6-bisphosphate aldolase subunit KbaY | |||
Sequence: MSIISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTYNMPLALHLDHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAESAFLTDPQEAKRFVELTGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFAGAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANRISA |
Interaction
Subunit
Homotetramer. Forms a complex with KbaZ.
Structure
Sequence
- Sequence statusComplete
- Length286
- Mass (Da)31,294
- Last updated2008-11-25 v1
- ChecksumCAA42DF05C2B918B
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001164 EMBL· GenBank· DDBJ | ACI38706.1 EMBL· GenBank· DDBJ | Genomic DNA |