B5YK79 · COAD_THEYD
- ProteinPhosphopantetheine adenylyltransferase
- GenecoaD
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids161 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
Catalytic activity
- (R)-4'-phosphopantetheine + ATP + H+ = 3'-dephospho-CoA + diphosphate
Cofactor
Pathway
Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 10 | substrate | |||
Binding site | 10-11 | ATP (UniProtKB | ChEBI) | |||
Binding site | 18 | ATP (UniProtKB | ChEBI) | |||
Site | 18 | Transition state stabilizer | |||
Binding site | 42 | substrate | |||
Binding site | 75 | substrate | |||
Binding site | 89 | substrate | |||
Binding site | 90-92 | ATP (UniProtKB | ChEBI) | |||
Binding site | 100 | ATP (UniProtKB | ChEBI) | |||
Binding site | 125-131 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | pantetheine-phosphate adenylyltransferase activity | |
Biological Process | coenzyme A biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphopantetheine adenylyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Nitrospirota > Thermodesulfovibrionia > Thermodesulfovibrionales > Thermodesulfovibrionaceae > Thermodesulfovibrio
Accessions
- Primary accessionB5YK79
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_1000118086 | 1-161 | Phosphopantetheine adenylyltransferase | ||
Interaction
Structure
Sequence
- Sequence statusComplete
- Length161
- Mass (Da)18,300
- Last updated2008-11-25 v1
- MD5 Checksum6AF5EBF075C1386C1CF273DD4ACE4B1E
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001147 EMBL· GenBank· DDBJ | ACI20782.1 EMBL· GenBank· DDBJ | Genomic DNA |