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B5YK79 · COAD_THEYD

Function

function

Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.

Features

Showing features for binding site, site.

Type
IDPosition(s)Description
Binding site10substrate
Binding site10-11ATP (UniProtKB | ChEBI)
Binding site18ATP (UniProtKB | ChEBI)
Site18Transition state stabilizer
Binding site42substrate
Binding site75substrate
Binding site89substrate
Binding site90-92ATP (UniProtKB | ChEBI)
Binding site100ATP (UniProtKB | ChEBI)
Binding site125-131ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionpantetheine-phosphate adenylyltransferase activity
Biological Processcoenzyme A biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphopantetheine adenylyltransferase
  • EC number
  • Alternative names
    • Dephospho-CoA pyrophosphorylase
    • Pantetheine-phosphate adenylyltransferase
      (PPAT
      )

Gene names

    • Name
      coaD
    • Ordered locus names
      THEYE_A0803

Organism names

Accessions

  • Primary accession
    B5YK79

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001180861-161Phosphopantetheine adenylyltransferase

Interaction

Subunit

Homohexamer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the bacterial CoaD family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    161
  • Mass (Da)
    18,300
  • Last updated
    2008-11-25 v1
  • MD5 Checksum
    6AF5EBF075C1386C1CF273DD4ACE4B1E
MTKTGVYPGTFDPITNGHLDVIKRALKIFDELIVAVAMSSYKKTPIFTVEERVHFIAQTTKDLKNLKVEVFDGLLVNFIKEKKAVAIVRGLRAVSDYEFELQLAHANRRLFRDIETVFLMPSEEYSFLSSSLVKEIAYFGGSVKSLVPPIVEKALRNKFKK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001147
EMBL· GenBank· DDBJ
ACI20782.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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