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B5YJD3 · METE_THEYD

Function

function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site17-205-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site1115-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site421-423L-homocysteine (UniProtKB | ChEBI)
Binding site421-423L-methionine (UniProtKB | ChEBI)
Binding site474L-homocysteine (UniProtKB | ChEBI)
Binding site474L-methionine (UniProtKB | ChEBI)
Binding site505-5065-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site5515-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site589L-homocysteine (UniProtKB | ChEBI)
Binding site589L-methionine (UniProtKB | ChEBI)
Binding site5955-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site631Zn2+ (UniProtKB | ChEBI); catalytic
Binding site633Zn2+ (UniProtKB | ChEBI); catalytic
Binding site655Zn2+ (UniProtKB | ChEBI); catalytic
Active site684Proton donor
Binding site716Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Molecular Function5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
Molecular Functionzinc ion binding
Biological Processmethionine biosynthetic process
Biological Processmethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
  • EC number
  • Alternative names
    • Cobalamin-independent methionine synthase
    • Methionine synthase, vitamin-B12 independent isozyme

Gene names

    • Name
      metE
    • Ordered locus names
      THEYE_A0504

Organism names

Accessions

  • Primary accession
    B5YJD3

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000978501-7455-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    745
  • Mass (Da)
    85,984
  • Last updated
    2008-11-25 v1
  • MD5 Checksum
    41C642035493E24C085B88F379BC152C
MKIKTTVFGYPRIGPKRELKKALEDYWNWKISKVELLETANSLIIQNAKVIQSSGVDLIPSNEFSLYDFILDHSVMFNAVPKRFNRISDPLDRYFAMARGTQELPALEMTKWFNTNYHYIVPEIEDEEFELMENKPLREFALLRDSLSVKTKPVIVGPFTYLKSAKLNMDRVERLSEKILPAYKKLLIKLDAAGVEEIQIDEPAMVMDMEEREIELLTGLYRELTKGLTLKVYIQTYYEAVSAYEKLVFSLSVHGFGFDLVDGKENLENILTLGFPSDKVLIAGVVSGRDPWRTDFTVVMSMLERLFRVTDKIMLSNSSPLIHLPITVEAERGHIQEDILNMLSFANERLEELTILKRAINDGAALPARKSIVHEIFSKAEVRSKISSIDEKAILRKPEFQERYRMQMDSLKLPLFPTTTIGSFPQTKEVRKFRADYKNGKITEEEYKKFIFQEIEKAVKIQEELDIDVLVHGEFERTDMVEFFAEKLKGFAITKNGWVQSYGSRCVRPPVIYGDVWRDKALTVEETLYAQSLTPRPVKGIMTGAVTILQWSYPRKDISRREIAYQIALALKEEVLELEKRGIKIIQIDEPAFREGLPLKRNKQDEYFDWTINSFRLTTADVSPFTQIHTHMCYSDFNEIIDRIYALDADVISIEASRSKGEILSAFENFRYDHGIGLGVYDIHSPRVPSVEEMIEIIERSVSLIDKSLFWINPDCGLKTRGWQETVASLKNMVLAAKAMRKREV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001147
EMBL· GenBank· DDBJ
ACI21086.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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