B5XLI1 · GUAC_STRPZ

Function

function

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.

Catalytic activity

Features

Showing features for active site, binding site.

132750100150200250300
Type
IDPosition(s)Description
Active site176Thioimidate intermediate
Binding site205-228NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular ComponentGMP reductase complex
Molecular FunctionGMP reductase activity
Biological Processpurine nucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GMP reductase
  • EC number
  • Alternative names
    • Guanosine 5'-monophosphate oxidoreductase
      (Guanosine monophosphate reductase
      )

Gene names

    • Name
      guaC
    • Ordered locus names
      Spy49_0885

Organism names

Accessions

  • Primary accession
    B5XLI1

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001461441-327GMP reductase

Structure

Family & Domains

Sequence similarities

Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    327
  • Mass (Da)
    35,915
  • Last updated
    2008-11-25 v1
  • Checksum
    1733CADB2F4A4A2D
MFNDIPVFDYEDIQLIPNKCIITSRSQADTSVTLGKYQFKLPVIPANMQTIIDETIAEQLAKEGYFYIMHRFDEDSRKPFIKRMHEQGLIASISVGVKACEYDFVTSLKEDAPEFITIDIAHGHANSVIDMIKHIKTELPETFVIAGNVGTPEAVRELENAGADATKVGIGPGKVCITKVKTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGASMVMIGSLFAGHIESPGKTVEVDGETFKEYYGSASEYQKGEHKNVEGKKILLPTKGHLSDTLTEMQQDLQSSISYAGGKDLDSLRHVDYVIVKNSIWNGDSI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000829
EMBL· GenBank· DDBJ
ACI61193.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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