B5SNS7 · B5SNS7_ADE41

Function

function

Plays a role in the elongation phase of viral strand displacement replication by unwinding the template in an ATP-independent fashion, employing its capacity to form multimers. Also enhances the rate of initiation. Released from template upon second strand synthesis. Assembles in complex with viral pTP, viral pol, host NFIA and host POU2F1/OCT1 on viral origin of replication. Covers the whole ssDNA genome during synthesis. The complementary strand synthesis induces its relese from DNA template. May inhibit cellular transcription mediated by the interaction between host SRCAP and CBP.

Features

Showing features for binding site.

147450100150200250300350400450
TypeIDPosition(s)Description
Binding site231Zn2+ 1 (UniProtKB | ChEBI)
Binding site233Zn2+ 1 (UniProtKB | ChEBI)
Binding site286Zn2+ 1 (UniProtKB | ChEBI)
Binding site302Zn2+ 1 (UniProtKB | ChEBI)
Binding site343Zn2+ 2 (UniProtKB | ChEBI)
Binding site345Zn2+ 2 (UniProtKB | ChEBI)
Binding site397Zn2+ 2 (UniProtKB | ChEBI)
Binding site413Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell nucleus
Cellular Componentviral capsid
Molecular FunctionDNA binding
Molecular Functionzinc ion binding
Biological ProcessDNA unwinding involved in DNA replication
Biological ProcessDNA-templated transcription
Biological Processpositive regulation of DNA replication
Biological Processviral DNA strand displacement replication

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    DNA-binding protein
  • Short names
    DBP
  • Alternative names
    • Early 2A protein
    • Early E2A DNA-binding protein

Gene names

    • Name
      DBP

Organism names

Accessions

  • Primary accession
    B5SNS7

Proteomes

Subcellular Location

Host nucleus
Note: Accumulates in infected cells.

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue142Phosphotyrosine; by host

Keywords

Expression

Keywords

Interaction

Subunit

Homomultimerizes on viral ssDNA bound to pTP. Forms a initiation complex with viral polymerase, pTP and hosts NFIA and POU2F1/OCT1. Interacts with host SRCAP.

Structure

3D structure databases

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-34Disordered
Domain132-206Adenovirus DNA-binding all-alpha
Domain229-330Adenovirus DNA-binding zinc-binding
Region244-278Flexible loop
Domain341-436Adenovirus DNA-binding zinc-binding
Region460-474C-terminal arm, DBP binding

Domain

The C-terminal arm bridges DBP molecules together, thereby creating a chain.

Sequence similarities

Belongs to the adenoviridae E2A DNA-binding protein family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    474
  • Mass (Da)
    53,658
  • Last updated
    2008-11-04 v1
  • Checksum
    4350AE593088B19E
MAGRQREHPTVTPYLQETSPERPPPLPPKKKLRKNLQVPEQVHAPALSPEVVPDSEEDEEVLYHGFSYPGVEVVQKGNGKRQIRRLEKTVIPRDLTPPEEEENNQSGSSKAVTMLITNPQVDPLVSAWEKGMELMNVLMEKYHVENDEKTAFKFLPEQNAVYRKICQTWLNEERRGLSLTFTTQKTFTELMGRFLAAYVETYAGVKHHNWDTTGCAVWAHGCTREEGVLRCFHGREMIQKEQVVEVDVGSENGQRALKEQPSKTKVVQNRWGRSVVQIKNDDARCCAEDVSCGNNMFSSKSCGLFFSEGLKAQIAFKQMQAFLQAEYPQMQRGQQRILVPLRCECLNKKDLVPQLGRQMCKVTPFALSGAEDLKTSEVTDKSALASILHPCVLVFQCANPVYRNSRGSAGPNCDFKISAPDVISALQLVRQFWKENVEDPLPKLIIPEFKWSTRLQYRNVALPTGHGDAEVEPF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ315364
EMBL· GenBank· DDBJ
ACH90438.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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