B5KVH4 · 11S1_CARIL
- Protein11S globulin seed storage protein 1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids505 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Seed storage protein.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | IgE binding | |
Molecular Function | nutrient reservoir activity | |
Biological Process | seed development | |
Biological Process | seed maturation |
Keywords
- Molecular function
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended name11S globulin seed storage protein 1
- Alternative names
- Cleaved into 2 chains
- Allergen nameCar i 4.0101
Organism names
- Organism
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Fagales > Juglandaceae > Carya
Accessions
- Primary accessionB5KVH4
Phenotypes & Variants
Allergenic properties
Causes an allergic reaction in human. Recombinant protein binds to IgE in 57% of the 28 patients tested allergic to pecan nuts. Acidic chain is more immunoreactive than the basic chain.
Keywords
- Disease
Protein family/group databases
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-24 | |||||
Sequence: MAKPILLSIYLCLIIVALFNGCLA | ||||||
Chain | PRO_0000448540 | 25-316 | 11S globulin seed storage protein 1 acidic chain | |||
Sequence: QSGGRQQHKFGQCQLNRLDALEPTNRIEAEAGVIESWDPNHQQLQCAGVAVVRRTIEPNGLLLPHYSNAPQLVYIARGRGITGVLFPGCPETFEESQRQSQQGQRREFQQDRHQKIRHFREGDIIAFPAGVAHWCYNDGSSPVVAIFLLDTHNNANQLDQNPRNFYLAGNPDDEFRPQGQQEYEQHRRQQQHQQRRGEHGEQQRDLGNNVFSGFDAEFLADAFNVDTETARRLQSENDHRGSIVRVEGRQLQVIRPRWSREEQEHEERKERERERESESERRQSRRGGRDDN | ||||||
Disulfide bond | 37↔70 | |||||
Sequence: CQLNRLDALEPTNRIEAEAGVIESWDPNHQQLQC | ||||||
Disulfide bond | 113↔323 | Interchain (between acidic and basic chains) | ||||
Sequence: CPETFEESQRQSQQGQRREFQQDRHQKIRHFREGDIIAFPAGVAHWCYNDGSSPVVAIFLLDTHNNANQLDQNPRNFYLAGNPDDEFRPQGQQEYEQHRRQQQHQQRRGEHGEQQRDLGNNVFSGFDAEFLADAFNVDTETARRLQSENDHRGSIVRVEGRQLQVIRPRWSREEQEHEERKERERERESESERRQSRRGGRDDNGLEETIC | ||||||
Chain | PRO_0000448541 | 317-505 | 11S globulin seed storage protein 1 basic chain | |||
Sequence: GLEETICTLSLRENIGDPSRADIYTEEAGRISTVNSHNLPILRWLQLSAERGALYSDALYVPHWNLNAHSVVYALRGRAEVQVVDNFGQTVFDDELREGQLLTIPQNFAVVKRARDEGFEWVSFKTNENAMVSPLAGRTSAIRALPEEVLVNAFQIPREDARRLKFNRQESTLVRSRSRSSRSERRAEV |
Keywords
- PTM
Expression
Tissue specificity
Induction
Up-regulated during nut development.
Developmental stage
Expressed during seed maturation (PubMed:21718052).
Expressed during embryonic development including the water, gel, dough and mature nut stages in the nut cavity tissues including the contents of the central vacuole, endosperm, embryo, placenta, seed coat, ovary packing tissue, developing fruit and cotyledon lobes. Expression increases during the transition from water to gel stage, levels off or decreases slightly from the gel to dough stage and increases again from the dough to mature stage (PubMed:28121438).
Expressed during embryonic development including the water, gel, dough and mature nut stages in the nut cavity tissues including the contents of the central vacuole, endosperm, embryo, placenta, seed coat, ovary packing tissue, developing fruit and cotyledon lobes. Expression increases during the transition from water to gel stage, levels off or decreases slightly from the gel to dough stage and increases again from the dough to mature stage (PubMed:28121438).
Interaction
Subunit
Homohexamer (By similarity).
Each subunit is composed of an acidic and a basic chain derived from a single precursor and linked by a disulfide bond (PubMed:21718052).
Each subunit is composed of an acidic and a basic chain derived from a single precursor and linked by a disulfide bond (PubMed:21718052).
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 42-255 | Cupin type-1 1 | ||||
Sequence: LDALEPTNRIEAEAGVIESWDPNHQQLQCAGVAVVRRTIEPNGLLLPHYSNAPQLVYIARGRGITGVLFPGCPETFEESQRQSQQGQRREFQQDRHQKIRHFREGDIIAFPAGVAHWCYNDGSSPVVAIFLLDTHNNANQLDQNPRNFYLAGNPDDEFRPQGQQEYEQHRRQQQHQQRRGEHGEQQRDLGNNVFSGFDAEFLADAFNVDTETAR | ||||||
Region | 118-132 | IgE-binding | ||||
Sequence: EESQRQSQQGQRREF | ||||||
Region | 193-232 | Disordered | ||||
Sequence: GNPDDEFRPQGQQEYEQHRRQQQHQQRRGEHGEQQRDLGN | ||||||
Compositional bias | 201-227 | Basic and acidic residues | ||||
Sequence: PQGQQEYEQHRRQQQHQQRRGEHGEQQ | ||||||
Region | 208-219 | IgE-binding | ||||
Sequence: EQHRRQQQHQQR | ||||||
Region | 238-249 | IgE-binding | ||||
Sequence: FDAEFLADAFNV | ||||||
Compositional bias | 282-317 | Basic and acidic residues | ||||
Sequence: WSREEQEHEERKERERERESESERRQSRRGGRDDNG | ||||||
Region | 282-318 | Disordered | ||||
Sequence: WSREEQEHEERKERERERESESERRQSRRGGRDDNGL | ||||||
Motif | 316-321 | NGXEET; peptidase recognition motif | ||||
Sequence: NGLEET | ||||||
Domain | 329-478 | Cupin type-1 2 | ||||
Sequence: ENIGDPSRADIYTEEAGRISTVNSHNLPILRWLQLSAERGALYSDALYVPHWNLNAHSVVYALRGRAEVQVVDNFGQTVFDDELREGQLLTIPQNFAVVKRARDEGFEWVSFKTNENAMVSPLAGRTSAIRALPEEVLVNAFQIPREDAR |
Sequence similarities
Belongs to the 11S seed storage protein (globulins) family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length505
- Mass (Da)58,016
- Last updated2008-10-14 v1
- Checksum4B4A57816D3D6D7E
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 201-227 | Basic and acidic residues | ||||
Sequence: PQGQQEYEQHRRQQQHQQRRGEHGEQQ | ||||||
Compositional bias | 282-317 | Basic and acidic residues | ||||
Sequence: WSREEQEHEERKERERERESESERRQSRRGGRDDNG |
Keywords
- Technical term