B5G2F0 · B5G2F0_TAEGU

Function

function

It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.
Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.

Catalytic activity

Pathway

Carbohydrate biosynthesis; gluconeogenesis.
Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmethylglyoxal synthase activity
Molecular Functionprotein homodimerization activity
Molecular Functiontriose-phosphate isomerase activity
Molecular Functionubiquitin protein ligase binding
Biological Processcanonical glycolysis
Biological Processgluconeogenesis
Biological Processglyceraldehyde-3-phosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Triosephosphate isomerase
  • EC number

Gene names

    • Name
      TPI1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Passeriformes > Passeroidea > Estrildidae > Estrildinae > Taeniopygia

Accessions

  • Primary accession
    B5G2F0

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the triosephosphate isomerase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    248
  • Mass (Da)
    26,665
  • Last updated
    2008-10-14 v1
  • Checksum
    8E1A12CEA7ABAD23
MAPRKFFVGGNWKMNGDKKSLGELIHTLNSAKLSADTEVVCGAPAIYLDFARQKLDAKIGVAAQNCYKVPKGAFTGEISPAMIKDIGAAWVILGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKAIADNVKDWSKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKSHVSDAVAQSTRIIYGGSVTGSNCKELASQHDVDGFLVGGASLKPEFVDIINAKH

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ216093
EMBL· GenBank· DDBJ
ACH45461.1
EMBL· GenBank· DDBJ
mRNA
DQ216095
EMBL· GenBank· DDBJ
ACH45462.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp