B5G2F0 · B5G2F0_TAEGU
- ProteinTriosephosphate isomerase
- GeneTPI1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids248 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.
Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.
Catalytic activity
- D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate
Pathway
Carbohydrate biosynthesis; gluconeogenesis.
Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | methylglyoxal synthase activity | |
Molecular Function | protein homodimerization activity | |
Molecular Function | triose-phosphate isomerase activity | |
Molecular Function | ubiquitin protein ligase binding | |
Biological Process | canonical glycolysis | |
Biological Process | gluconeogenesis | |
Biological Process | glyceraldehyde-3-phosphate biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTriosephosphate isomerase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Passeriformes > Passeroidea > Estrildidae > Estrildinae > Taeniopygia
Accessions
- Primary accessionB5G2F0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length248
- Mass (Da)26,665
- Last updated2008-10-14 v1
- Checksum8E1A12CEA7ABAD23
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DQ216093 EMBL· GenBank· DDBJ | ACH45461.1 EMBL· GenBank· DDBJ | mRNA | ||
DQ216095 EMBL· GenBank· DDBJ | ACH45462.1 EMBL· GenBank· DDBJ | mRNA |