B5DFK7 · AB17C_RAT

  • Protein
    Alpha/beta hydrolase domain-containing protein 17C
  • Gene
    Abhd17c
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards DLG4/PSD95.

Catalytic activity

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site202Charge relay system
Active site267Charge relay system
Active site296Charge relay system

GO annotations

AspectTerm
Cellular Componentdendritic spine
Cellular Componentendosome membrane
Cellular Componentglutamatergic synapse
Cellular Componentplasma membrane
Cellular Componentpostsynaptic density
Cellular Componentpostsynaptic density membrane
Cellular Componentrecycling endosome membrane
Molecular Functionpalmitoyl-(protein) hydrolase activity
Biological Processnegative regulation of protein localization to microtubule
Biological Processpositive regulation of protein localization to endosome
Biological Processregulation of postsynapse organization

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Alpha/beta hydrolase domain-containing protein 17C
  • EC number
  • Short names
    Abhydrolase domain-containing protein 17C

Gene names

    • Name
      Abhd17c

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    B5DFK7
  • Secondary accessions
    • Q3B7U5

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004431111-320Alpha/beta hydrolase domain-containing protein 17C

Post-translational modification

Palmitoylated on cysteine residues located in a cysteine cluster at the N-terminus which promotes membrane localization. Palmitoylation is required for post-synaptic localization and for depalmitoylating activity towards DLG4/PSD95.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in brain (at protein level).

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region50-75Disordered

Sequence similarities

Belongs to the AB hydrolase superfamily. ABHD17 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    320
  • Mass (Da)
    35,098
  • Last updated
    2008-10-14 v1
  • Checksum
    756E2E43EF5399A4
MPEPGPRMNGFSLGELCWLFCCPPCPSRIAAKLAFLPPEPTYTVLAPEQRAPAPAATPAPAPAAQPAPAEEGAGPGACSLHLSERADWQYSQRELDAVEVFFSRTARDNRLGCMFVRCAPSSRYTLLFSHGNAVDLGQMCSFYIGLGSRINCNIFSYDYSGYGVSSGKPSEKNLYADIDAAWQALRTRYGVSPENIILYGQSIGTVPTVDLASRYECAAVILHSPLMSGLRVAFPDTRKTYCFDAFPSIDKISKVTSPVLVIHGTEDEVIDFSHGLAMYERCPRAVEPLWVEGAGHNDIELYAQYLERLKQFISHELPNS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AABR07004495
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH473980
EMBL· GenBank· DDBJ
EDM08764.1
EMBL· GenBank· DDBJ
Genomic DNA
BC107461
EMBL· GenBank· DDBJ
AAI07462.1
EMBL· GenBank· DDBJ
mRNA
BC169098
EMBL· GenBank· DDBJ
AAI69098.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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