B5DFK7 · AB17C_RAT
- ProteinAlpha/beta hydrolase domain-containing protein 17C
- GeneAbhd17c
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids320 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards DLG4/PSD95.
Catalytic activity
- H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H+ + hexadecanoate + L-cysteinyl-[protein]
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 202 | Charge relay system | ||||
Sequence: S | ||||||
Active site | 267 | Charge relay system | ||||
Sequence: D | ||||||
Active site | 296 | Charge relay system | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | dendritic spine | |
Cellular Component | endosome membrane | |
Cellular Component | glutamatergic synapse | |
Cellular Component | plasma membrane | |
Cellular Component | postsynaptic density | |
Cellular Component | postsynaptic density membrane | |
Cellular Component | recycling endosome membrane | |
Molecular Function | palmitoyl-(protein) hydrolase activity | |
Biological Process | negative regulation of protein localization to microtubule | |
Biological Process | positive regulation of protein localization to endosome | |
Biological Process | regulation of postsynapse organization |
Keywords
- Molecular function
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameAlpha/beta hydrolase domain-containing protein 17C
- EC number
- Short namesAbhydrolase domain-containing protein 17C
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionB5DFK7
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000443111 | 1-320 | Alpha/beta hydrolase domain-containing protein 17C | |||
Sequence: MPEPGPRMNGFSLGELCWLFCCPPCPSRIAAKLAFLPPEPTYTVLAPEQRAPAPAATPAPAPAAQPAPAEEGAGPGACSLHLSERADWQYSQRELDAVEVFFSRTARDNRLGCMFVRCAPSSRYTLLFSHGNAVDLGQMCSFYIGLGSRINCNIFSYDYSGYGVSSGKPSEKNLYADIDAAWQALRTRYGVSPENIILYGQSIGTVPTVDLASRYECAAVILHSPLMSGLRVAFPDTRKTYCFDAFPSIDKISKVTSPVLVIHGTEDEVIDFSHGLAMYERCPRAVEPLWVEGAGHNDIELYAQYLERLKQFISHELPNS |
Post-translational modification
Palmitoylated on cysteine residues located in a cysteine cluster at the N-terminus which promotes membrane localization. Palmitoylation is required for post-synaptic localization and for depalmitoylating activity towards DLG4/PSD95.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 50-75 | Disordered | ||||
Sequence: RAPAPAATPAPAPAAQPAPAEEGAGP |
Sequence similarities
Belongs to the AB hydrolase superfamily. ABHD17 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length320
- Mass (Da)35,098
- Last updated2008-10-14 v1
- Checksum756E2E43EF5399A4
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AABR07004495 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH473980 EMBL· GenBank· DDBJ | EDM08764.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC107461 EMBL· GenBank· DDBJ | AAI07462.1 EMBL· GenBank· DDBJ | mRNA | ||
BC169098 EMBL· GenBank· DDBJ | AAI69098.1 EMBL· GenBank· DDBJ | mRNA |