B5DEL3 · TTC17_RAT
- ProteinTetratricopeptide repeat protein 17
- GeneTtc17
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1198 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Plays a role in primary ciliogenesis by modulating actin polymerization.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | actin cytoskeleton | |
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | plasma membrane | |
Biological Process | actin filament polymerization | |
Biological Process | cilium organization |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameTetratricopeptide repeat protein 17
- Short namesTPR repeat protein 17
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionB5DEL3
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Localized with CATIP at F-actin rich zones and at dynamic plasma membrane protrusions.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000426008 | 1-1198 | Tetratricopeptide repeat protein 17 | ||
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in germ cells as well as in somatic cells of the testis (at protein level). Ubiquitous.
Gene expression databases
Interaction
Structure
Family & Domains
Features
Showing features for repeat, coiled coil, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Repeat | 295-328 | TPR 1 | |||
Coiled coil | 340-382 | ||||
Repeat | 619-652 | TPR 2 | |||
Repeat | 689-722 | TPR 3 | |||
Region | 771-825 | Disordered | |||
Compositional bias | 776-807 | Basic and acidic residues | |||
Region | 903-924 | Disordered | |||
Repeat | 1071-1105 | TPR 4 | |||
Repeat | 1108-1141 | TPR 5 | |||
Repeat | 1142-1175 | TPR 6 | |||
Sequence similarities
Belongs to the TTC17 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,198
- Mass (Da)135,721
- Last updated2008-10-14 v1
- ChecksumFDAB1ABF199D83AC
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8I6GIU8 | A0A8I6GIU8_RAT | Ttc17 | 1141 | ||
A0A8I5ZKB8 | A0A8I5ZKB8_RAT | Ttc17 | 956 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 776-807 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AABR06024800 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AABR06024801 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AABR06024802 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AABR06024803 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC168714 EMBL· GenBank· DDBJ | AAI68714.1 EMBL· GenBank· DDBJ | mRNA |