B5DEL3 · TTC17_RAT

  • Protein
    Tetratricopeptide repeat protein 17
  • Gene
    Ttc17
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Plays a role in primary ciliogenesis by modulating actin polymerization.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentactin cytoskeleton
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentplasma membrane
Biological Processactin filament polymerization
Biological Processcilium organization

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Tetratricopeptide repeat protein 17
  • Short names
    TPR repeat protein 17

Gene names

    • Name
      Ttc17

Organism names

  • Taxonomic identifier
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    B5DEL3
  • Secondary accessions
    • F1MA48

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Cell membrane
Note: Localized with CATIP at F-actin rich zones and at dynamic plasma membrane protrusions.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004260081-1198Tetratricopeptide repeat protein 17

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in germ cells as well as in somatic cells of the testis (at protein level). Ubiquitous.

Gene expression databases

Interaction

Subunit

Interacts with CATIP.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for repeat, coiled coil, region, compositional bias.

Type
IDPosition(s)Description
Repeat295-328TPR 1
Coiled coil340-382
Repeat619-652TPR 2
Repeat689-722TPR 3
Region771-825Disordered
Compositional bias776-807Basic and acidic residues
Region903-924Disordered
Repeat1071-1105TPR 4
Repeat1108-1141TPR 5
Repeat1142-1175TPR 6

Sequence similarities

Belongs to the TTC17 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,198
  • Mass (Da)
    135,721
  • Last updated
    2008-10-14 v1
  • Checksum
    FDAB1ABF199D83AC
MAAAIGVRGRFELLSCSGPGWLISLSALLSVVARGALATTHWVVTEDGKIQQQVDSPMNLKHPHDLVILMRQETTVNYLKELEKQLVAQKIHIEENEDRDTGLEQRHNKEDPDCIKAKVPLGDLDLYDGTYITLESKDVRPEDFIDTESPVPPDPEQPDCTKILELPYSIHAFQHLRGVQERVNLSAPLLPKEDPIFTYLSKRLGRSIDDIGHLIHEGLQKNSSSWVLYNLASFYWRIKNEPYQVVECTMRALHFSSRHNKDIALVNLANVLHRAHFSADAAVVVHAALDDSAFFTSYYTLGNIYAMLGEYNHSVLCYDHALQAKPGFEQAIKRKHAVLCQQKLEQKLEAQHRSLQRTLNELKEYQKQHDHYLRQQEILEKHKLIQEEQILRNIIHETQMAKEAQLGNHQICRLVNQQHSLHCQWDQPVRYHRGDIFENVDYVQFGDDSSTSSMMSVNFDVPTNQSDVSESVRSSPVAHSVLWVWGRDSDAYRDKQHILWPKRADCTDSYPRVPLGGELPTYFLPPENKGLRIHELTSDDYSSEEEAQTPDCSITDFRKSHTLSYLVKELEVRMDLKAKIPDDHARKILLSRIKNYTIPEEEIGSFLFHAINKPNAPVWLILNEAGLYWRAVGNSTFAIACLQRALNLAPVQYQDIPLVNLANLLIHYGLHLDATKLLLQALAVNSSEPLTFLSLGNAYLALKNVSGALEAFRQALKLTTRCPECESSLKLIRCMQFYPFLYNITSSVCSGHCHEKTLDNSHDKQKYFAKPQSLDAAEEEPSRHGADEDPVLSVENAGRDSDALRLESTVVEESNGSDEVEKSEETKMSEEILALVDEFQQAWPLEGLGGTLEMKGRRLDLQGIRVLKKGPQDGVAKSSCYGDCRSEDDEATEWITFQVKRVKKPKGDHKKPPGKKVEASQAENGQRYQANLEITGPKVASPGPQEKKRDYQSMGWPSPDECLKLRWVELTAIVSTWLAVSSKNIDITEHIDFATPIQQPAMEPLCNGNLPTSMHTLDHLHGVSNRASLHYTGESQLTEVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTSWVLSSMAALYWRVKGQGKKAIDCLRQALHYAPHQMKDVPLISLANILHNAKLWNDAVVVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQTIQCHLMLKKGRRSP

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I6GIU8A0A8I6GIU8_RATTtc171141
A0A8I5ZKB8A0A8I5ZKB8_RATTtc17956

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias776-807Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AABR06024800
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AABR06024801
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AABR06024802
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AABR06024803
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC168714
EMBL· GenBank· DDBJ
AAI68714.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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