B4V386 · B4V386_9ACTN

  • Protein
    Phosphoribosyl isomerase A
  • Gene
    priA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Involved in both the histidine and tryptophan biosynthetic pathways.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.
Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site13Proton acceptor
Active site132Proton donor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity
Molecular Functionphosphoribosylanthranilate isomerase activity
Biological ProcessL-histidine biosynthetic process
Biological Processtryptophan biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosyl isomerase A
  • Alternative names
    • 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
      (EC:5.3.1.16
      ) . EC:5.3.1.16 (UniProtKB | ENZYME | Rhea)
    • N-(5'-phosphoribosyl)anthranilate isomerase
      (PRAI
      ) (EC:5.3.1.24
      ) . EC:5.3.1.24 (UniProtKB | ENZYME | Rhea)
    • Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Gene names

    • Name
      priA
    • Synonyms
      hisA
    • ORF names
      M444_10495

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Mg1
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces

Accessions

  • Primary accession
    B4V386

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the HisA/HisF family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    243
  • Mass (Da)
    25,034
  • Last updated
    2008-09-23 v1
  • Checksum
    DC02E6585F520418
MPVNKLELLPAVDVRDGQAVRLVHGVSGSETSYGSPLEAALAWQASGAEWLHLVDLDAAFGTGDNRALVAEITGAMDIKVELSGGIRDDASLAAALATGCTRVNLGTAALETPEWAAKAIAEHGDRIAVGLDVRGTTLKGRGWTSEGGDLYETLARLDSEGCARYVVTDIGKDGTLTGPNLELLKNVCAATDRPVVASGGISSLEDLRALAALVPQGVEGAIVGKALYAKAFTLEEALKVVSA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP011664
EMBL· GenBank· DDBJ
AKL65755.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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