B4T6B6 · GARL_SALNS

Function

function

Catalyzes the reversible retro-aldol cleavage of both 5-keto-4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Carbohydrate acid metabolism; galactarate degradation; D-glycerate from galactarate: step 2/3.

Features

Showing features for active site, site, binding site.

Type
IDPosition(s)Description
Active site50Proton acceptor
Site75Transition state stabilizer
Site89Increases basicity of active site His
Binding site151substrate
Binding site153Mg2+ (UniProtKB | ChEBI)
Binding site178substrate
Binding site179Mg2+ (UniProtKB | ChEBI)
Binding site179substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function2-dehydro-3-deoxyglucarate aldolase activity
Molecular Functionmagnesium ion binding
Biological ProcessD-glucarate catabolic process
Biological Processgalactarate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    5-keto-4-deoxy-D-glucarate aldolase
  • EC number
  • Short names
    KDGluc aldolase
    ; KDGlucA
  • Alternative names
    • 2-dehydro-3-deoxy-D-glucarate aldolase
    • 2-keto-3-deoxy-D-glucarate aldolase
    • 5-dehydro-4-deoxy-D-glucarate aldolase
    • Alpha-keto-beta-deoxy-D-glucarate aldolase

Gene names

    • Name
      garL
    • Ordered locus names
      SNSL254_A3511

Organism names

Accessions

  • Primary accession
    B4T6B6

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001404161-2565-keto-4-deoxy-D-glucarate aldolase

Interaction

Subunit

Homohexamer; trimer of dimers.

Structure

Family & Domains

Sequence similarities

Belongs to the HpcH/HpaI aldolase family. KDGluc aldolase subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    256
  • Mass (Da)
    27,321
  • Last updated
    2008-09-23 v1
  • Checksum
    41EFEBE9EE3A2AFA
MNNAIFPNKFKAALAAQQVQIGCWSALASPITTEVLGLAGFDWLVLDGEHAPNDVTTLIPQLMALKGSASAPVVRVPTNEPVIIKRMLDIGFYNFLIPFVETQEEAARAVASTRYPPEGIRGVSVSHRANMFGTVPDYFAQSNKNITIIVQIESQLGVDNVDAIAATEGVDGIFVGPSDLAAALGHLGNASHPDVQQTIQHIFARAKAHGKPCGILAPVEADARRYLEWGATFVAVGSDLGAFRASTQKLADTFKK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001113
EMBL· GenBank· DDBJ
ACF64925.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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