B4SUN2 · MSRP_SALNS

Function

function

Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.

Catalytic activity

Cofactor

Mo-molybdopterin (UniProtKB | Rhea| CHEBI:71302 )

Note: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site88Mo-molybdopterin (UniProtKB | ChEBI)
Binding site91-92Mo-molybdopterin (UniProtKB | ChEBI)
Binding site146Mo (UniProtKB | ChEBI) of Mo-molybdopterin (UniProtKB | ChEBI)
Binding site181Mo-molybdopterin (UniProtKB | ChEBI)
Binding site233Mo-molybdopterin (UniProtKB | ChEBI)
Binding site238Mo-molybdopterin (UniProtKB | ChEBI)
Binding site249-251Mo-molybdopterin (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentperiplasmic space
Molecular Functionmetal ion binding
Molecular Functionmolybdopterin cofactor binding
Molecular Functionoxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor
Biological Processprotein repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein-methionine-sulfoxide reductase catalytic subunit MsrP
  • EC number

Gene names

    • Name
      msrP
    • Ordered locus names
      SNSL254_A3640

Organism names

Accessions

  • Primary accession
    B4SUN2

Proteomes

Subcellular Location

Periplasm
Note: Is attached to the inner membrane when interacting with the MsrQ subunit.

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-44Tat-type signal
ChainPRO_100013872345-334Protein-methionine-sulfoxide reductase catalytic subunit MsrP

Post-translational modification

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

Interaction

Subunit

Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).

Structure

Family & Domains

Sequence similarities

Belongs to the MsrP family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    334
  • Mass (Da)
    37,492
  • Last updated
    2008-09-23 v1
  • Checksum
    EDC459B96461A08C
MKKIRPLTEADVTAESAFFMQRRQVLKALGISAAALSLPSTAQADLFSWFKGNDRPKAPAGKPLEFSQPAAWRSDLALTPEDKVTGYNNFYEFGLDKADPAANAGSLKTEPWTLKISGEVAKPFTLDYDDLTHRFPLEERIYRMRCVEAWSMVVPWIGFPLYKLLAQAQPTSHAKYVAFETLYAPDDMPGQKDRFIGGGLKYPYVEGLRLDEAMHPLTLMTVGVYGKALPPQNGAPIRLIVPWKYGFKGIKSIVSIKLTRERPPTTWNLSAPNEYGFYANVNPHVDHPRWSQATERFIGSGGILDVQRQPTLLFNGYANEVASLYRGLNLRENF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001113
EMBL· GenBank· DDBJ
ACF64022.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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