B4SIF5 · DPO4_STRM5

Function

function

Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 magnesium ions per subunit.

Features

Showing features for binding site, site, active site.

TypeIDPosition(s)Description
Binding site11Mg2+ (UniProtKB | ChEBI)
Site16Substrate discrimination
Binding site105Mg2+ (UniProtKB | ChEBI)
Active site106

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functiondamaged DNA binding
Molecular FunctionDNA-directed DNA polymerase activity
Molecular Functionmagnesium ion binding
Biological ProcessDNA repair
Biological ProcessDNA-templated DNA replication

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA polymerase IV
  • EC number
  • Short names
    Pol IV

Gene names

    • Name
      dinB
    • Ordered locus names
      Smal_0455

Organism names

Accessions

  • Primary accession
    B4SIF5

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001371471-356DNA polymerase IV

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-187UmuC

Sequence similarities

Belongs to the DNA polymerase type-Y family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    356
  • Mass (Da)
    39,846
  • Last updated
    2008-09-23 v1
  • Checksum
    BCB01846EBF2050E
MTRLRKIIHVDMDAFYASVEQRDDPSLRGKPVVVAWRGARSVVCAASYEARVFGVRSAMPAVRAERLCPDAIFVPPDFARYKAVSQQVREIFLRHTDLVEPLSLDEAYLDVTEPKSGMELATDIARTIRAQIREETQLTASAGIAPNKFLAKIASDWRKPDGQFVIPPQRVDAFLLPLPVNRVPGVGKVMEGKLAARGIVTCGDLRQWALIDLEEAFGSFGRSLYNRARGVDERPVEPDQQVQSISSEDTFAEDLPLEDLGEAIVQLAEKTWNATRKTERVGHTVVLKLKTAQFRILTRSFTPERPPESMEELRDIALALRARVDLPADTRYRLVGVGLSGFRDKEPVVQGELFEH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001111
EMBL· GenBank· DDBJ
ACF50160.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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