B4RJT2 · PYRC_NEIG2

Function

function

Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.

Features

Showing features for binding site, active site.

134450100150200250300
TypeIDPosition(s)Description
Binding site13Zn2+ 1 (UniProtKB | ChEBI)
Binding site15Zn2+ 1 (UniProtKB | ChEBI)
Binding site15-17substrate
Binding site41substrate
Binding site98Zn2+ 1 (UniProtKB | ChEBI); via carbamate group
Binding site98Zn2+ 2 (UniProtKB | ChEBI); via carbamate group
Binding site135substrate
Binding site135Zn2+ 2 (UniProtKB | ChEBI)
Binding site173Zn2+ 2 (UniProtKB | ChEBI)
Binding site218substrate
Active site247
Binding site247Zn2+ 1 (UniProtKB | ChEBI)
Binding site251substrate
Binding site263substrate

GO annotations

AspectTerm
Molecular Functiondihydroorotase activity
Molecular Functionzinc ion binding
Biological Process'de novo' UMP biosynthetic process
Biological Processpyrimidine nucleobase biosynthetic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydroorotase
  • EC number
  • Short names
    DHOase

Gene names

    • Name
      pyrC
    • Ordered locus names
      NGK_0392

Organism names

Accessions

  • Primary accession
    B4RJT2

Proteomes

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_10001000501-344Dihydroorotase
Modified residue98N6-carboxylysine

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    344
  • Mass (Da)
    37,055
  • Last updated
    2008-09-23 v1
  • Checksum
    DE8AFD2A9D65201B
MQTLTIIRPDDMHLHLRDGDALKAVAPYTARQMGRAVIMPNLKPPVVSVADALAYKARIMAALPEGSAFEPLMTLYLTDQATPELVREAKAAGIVAFKLYPAGATTNSDSGVTDLFKLIPVLEEMAKQGILFLVHGEVTDPEIDIFDREAAFIGRVMKPVLAQVPNLKVVFEHITTAEAARLVLEAGDNVAASVTPQHLLLNRNDLLVGGVRPHHFCLPVLKRETHRQALVAAVTGEKAHKFFLGTDSAPHAKSAKENACGCAGMFSAMTAIELYAEVFEKAGALDKLEAFASENGARFYGIPENADTITLVKQSQTVPASVPYGDGELVPMRAGGEIGWTVQY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001050
EMBL· GenBank· DDBJ
ACF29083.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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