B4RFS3 · MRAY_PHEZH

Function

function

Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionmetal ion binding
Molecular Functionphospho-N-acetylmuramoyl-pentapeptide-transferase activity
Molecular FunctionUDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity
Biological Processcell division
Biological Processcell wall organization
Biological Processpeptidoglycan biosynthetic process
Biological Processregulation of cell shape

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phospho-N-acetylmuramoyl-pentapeptide-transferase
  • EC number
  • Alternative names
    • UDP-MurNAc-pentapeptide phosphotransferase

Gene names

    • Name
      mraY
    • Ordered locus names
      PHZ_c2326

Organism names

Accessions

  • Primary accession
    B4RFS3

Proteomes

Subcellular Location

Cell inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane30-50Helical
Transmembrane74-94Helical
Transmembrane97-117Helical
Transmembrane136-156Helical
Transmembrane177-197Helical
Transmembrane208-228Helical
Transmembrane244-264Helical
Transmembrane272-292Helical
Transmembrane297-317Helical
Transmembrane346-366Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000906541-369Phospho-N-acetylmuramoyl-pentapeptide-transferase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    369
  • Mass (Da)
    40,011
  • Last updated
    2008-09-23 v1
  • Checksum
    D72E790E38B7BC10
MFYWLYEQFAASGYVPILNLLKYQTFRTGLAIFTAQFVVVAMGSRFIRWMQAKQGKGQPIRAEGIERHVIEKAGTPTMGGVMILAGLLVGTLLWSDLSNPYVWAVVLVTAGYGLLGFTDDYAKVTRQTTAGVSGKIRLALEAFIAMAAVLIIIVFAQKPPENPELLTSVTFPIFKQYFVDLSWGYLLFGAFIIVGAANAVNFTDGLDGLATVPVMIAAAAYGLIAYLVGNYVFSNYLQLHFVPGVGEIAVFCGALIGSGLGFLWYNAPPAKIFMGDTGSLALGGAVGAVAVATRHEIVLAIIGGLFVAETLSVIIQVAWFKRTGRRIFLMAPIHHHFEKLGWSESTVVIRFWIVAIMLALVGLATLKLR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000747
EMBL· GenBank· DDBJ
ACG78736.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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