B4R8U3 · KATG_PHEZH

Function

function

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.

Catalytic activity

Cofactor

heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.

Features

Showing features for site, active site, binding site.

TypeIDPosition(s)Description
Site94Transition state stabilizer
Active site98Proton acceptor
Binding site264Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncatalase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processcellular response to hydrogen peroxide
Biological Processhydrogen peroxide catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Catalase-peroxidase
  • EC number
  • Short names
    CP
  • Alternative names
    • Peroxidase/catalase

Gene names

    • Name
      katG
    • Ordered locus names
      PHZ_c2899

Organism names

Accessions

  • Primary accession
    B4R8U3

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain, cross-link.

TypeIDPosition(s)Description
ChainPRO_00003548581-745Catalase-peroxidase
Cross-link97↔223Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-249)
Cross-link223↔249Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-97)

Post-translational modification

Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.

Interaction

Subunit

Homodimer or homotetramer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region345-368Disordered

Sequence similarities

Belongs to the peroxidase family. Peroxidase/catalase subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    745
  • Mass (Da)
    81,913
  • Last updated
    2008-09-23 v1
  • Checksum
    02BD6F645AFC27A4
MDDASPLSNPAKEPAALRSLLGRTNRDWWPNQLSLDILHQHGRHGNPMGDDFDYAEAFKTLDYFAVKRDLHALMTDSQPWWPADYGHYGPFFIRMAWHSAGTYRTGDGRGGANSGNQRFAPLNSWPDNANLDKARRLLWPVKKKYGAKLSWADLMIMAGNVAFESMGAPVFGFGGGRADIFEPEKDVYWGTEEQWVGKGAKTRIVEGKAFEDPLAAVQMGLIYVNPEGPDGSPDPWASARDIRMTFARMGMNDEETLALTAGGHTFGKCHGAGDAAKIGAEPEGADIAQQGLGWTSSHESGMGDHTITSGLEGPWTPTPIKWDMSYFHMLLDYKYELVRSPAGAKQWQPVNPKPEDLAPGAHSPDRRVPTMMTTADLAFAMDPEYRKIAERFRDNPDQFADAFARAWFKLCHRDMGPKSRYLGPEVPAEDLIWQDPIPPVDHPLAEAADIASLKAKLLDSGLSVADLVRTAWASAATYRGSDHRGGANGARIRLAPQKDWEVNEPEKLARVLGVLEKVKADFDASAGGGKKISLADLIVLGGCAGIEKAARDAGHAIEVPFAPGRTDASPEQTDVESFEVLEPKADGFRNYLQVRFSVPTEELLIDRSQLLGLSAPEMTVLVGGLRVLGVNHGGSKNGVFTDRPGQLTNDFFVNLLDMGTAWKQVDDKADDLFVGTCRRTHEEKWTATRTDLVFGSNSQLRALSEVYASDDAGERFVKDFVRAWTKVMNADRFDLPRAQRLARAA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000747
EMBL· GenBank· DDBJ
ACG79308.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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