B4NI70 · B4NI70_DROWI
- ProteinKatanin p60 ATPase-containing subunit A1
- GeneKATNA1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids574 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.
Catalytic activity
Activity regulation
ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell cortex | |
Cellular Component | cell leading edge | |
Cellular Component | centrosome | |
Cellular Component | chromosome | |
Cellular Component | cytoplasmic microtubule | |
Cellular Component | spindle pole | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | isomerase activity | |
Molecular Function | microtubule binding | |
Molecular Function | microtubule severing ATPase activity | |
Molecular Function | myosin binding | |
Biological Process | cell division | |
Biological Process | cytoplasmic microtubule organization | |
Biological Process | dendrite development | |
Biological Process | microtubule depolymerization | |
Biological Process | microtubule severing | |
Biological Process | mitotic sister chromatid segregation | |
Biological Process | negative regulation of cell migration | |
Biological Process | regulation of synaptic assembly at neuromuscular junction |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameKatanin p60 ATPase-containing subunit A1
- EC number
- Short namesKatanin p60 subunit A1
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionB4NI70
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Note: Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1.
Keywords
- Cellular component
Interaction
Subunit
Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 113-270 | Disordered | ||||
Sequence: LRSQSNSEESNSNYKDPAAWFKPDPDIWTPPPKDPDVWGPPKQPAPTQTVGRRANATNSRRTTNSSNSASTQQRIPQSTTRNGPNAARNARSSNSARSTNSTTASTTSNGRRKLSTANNNEVKDDDSAAASNGANGGDNGEPDSQTGGADEERKFQPN | ||||||
Compositional bias | 136-154 | Pro residues | ||||
Sequence: DPDIWTPPPKDPDVWGPPK | ||||||
Compositional bias | 160-254 | Polar residues | ||||
Sequence: QTVGRRANATNSRRTTNSSNSASTQQRIPQSTTRNGPNAARNARSSNSARSTNSTTASTTSNGRRKLSTANNNEVKDDDSAAASNGANGGDNGEP | ||||||
Domain | 327-466 | AAA+ ATPase | ||||
Sequence: PWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSATLTSKYRGESEKMVRLLFEMARFYAPSTIFIDEIDSLCSRRGSESEHEASRRVKSELLVQMDGVGGSEEQAKVVMVLAATNFPWDIDEALRRRLEKRIYIPLPS |
Sequence similarities
Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length574
- Mass (Da)63,928
- Last updated2008-09-23 v1
- ChecksumA88068B6095BEEF3
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 136-154 | Pro residues | ||||
Sequence: DPDIWTPPPKDPDVWGPPK | ||||||
Compositional bias | 160-254 | Polar residues | ||||
Sequence: QTVGRRANATNSRRTTNSSNSASTQQRIPQSTTRNGPNAARNARSSNSARSTNSTTASTTSNGRRKLSTANNNEVKDDDSAAASNGANGGDNGEP |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CH964272 EMBL· GenBank· DDBJ | EDW84762.1 EMBL· GenBank· DDBJ | Genomic DNA |