B4L535 · SWS_DROMO
- ProteinNeuropathy target esterase sws
- Genesws
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1488 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain (By similarity).
Catalytic activity
- a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 175-302 | a nucleoside 3',5'-cyclic phosphate 1 (UniProtKB | ChEBI) | ||||
Sequence: IFGHFEKPIFLKLCKHTQLLQLMAGDYLFKITDPDDSVYIVQSGMINVYICNADGSTLSLKTVRKGESVTSLLSFIDVLSGNSSYYKTVTAKAMEKSVVIRLPMQAFEEVFNENPDVMIRVIQVIMIR | ||||||
Binding site | 458-587 | a nucleoside 3',5'-cyclic phosphate 2 (UniProtKB | ChEBI) | ||||
Sequence: ELGLSEEDTSIIEPFVEVRELEPNVTLITEGNAEDVCIWFVMTGTLAVYQSNADATRAAKQDSKNDMLIHFVHPGEIVGGLAMLTGEASAYTIRARSNSRIAYIRRAAIYQIMRQRPRIVLDLGNGVVRR | ||||||
Binding site | 576-703 | a nucleoside 3',5'-cyclic phosphate 3 (UniProtKB | ChEBI) | ||||
Sequence: IVLDLGNGVVRRLSPLVRQCDYALDWIFLESGRAVYRQDESSDSTYIVLSGRMRSVITHPGGKKEIVGEYGKGDLVGIVEMITETSRTTTVLAVRDSELAKLPEGLFNAIKLRYPIVVTRLISFLSHR | ||||||
Active site | 962 | Nucleophile | ||||
Sequence: S | ||||||
Active site | 1082 | Proton acceptor | ||||
Sequence: D |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | plasma membrane | |
Molecular Function | lysophospholipase activity | |
Molecular Function | protein kinase A catalytic subunit binding | |
Biological Process | ensheathment of neurons | |
Biological Process | glial cell apoptotic process | |
Biological Process | lipid catabolic process | |
Biological Process | membrane lipid metabolic process | |
Biological Process | membrane organization | |
Biological Process | neuron apoptotic process | |
Biological Process | phosphatidylcholine metabolic process | |
Biological Process | photoreceptor cell maintenance | |
Biological Process | protein localization to membrane | |
Biological Process | sensory perception of smell |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameNeuropathy target esterase sws
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila
Accessions
- Primary accessionB4L535
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Single-pass type I membrane protein
Note: Sws tethers Pka-C3 to the membrane.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-34 | Lumenal | ||||
Sequence: MDVLELLRASVNGCYNTLFSDAWSQYVSKQIATT | ||||||
Transmembrane | 35-55 | Helical | ||||
Sequence: TYWYGALLAIGALFIAWFLYF | ||||||
Topological domain | 56-1488 | Cytoplasmic | ||||
Sequence: KRLASLRLRDESARTLSALTAASGGDHRGLRFRKRDKMLFYGRRMLRKMKNVSGQMYSSGKGYKRRAVMRFARRILQLQRENRPLEMKTVEPPAEYLEETIDGSDRVPPDALYMLQSIRIFGHFEKPIFLKLCKHTQLLQLMAGDYLFKITDPDDSVYIVQSGMINVYICNADGSTLSLKTVRKGESVTSLLSFIDVLSGNSSYYKTVTAKAMEKSVVIRLPMQAFEEVFNENPDVMIRVIQVIMIRLQRVLFTALRNYLGLNAELVQNHMRIKGSNPVPVTVPGPVLSQASQASRAMASRPATSPVTRMSREEHTLSDPDPNPNASAMLFAEVHGDAPYIDLYHHQQQQSSGVSVGGTHRSSGACTPTGSGGESPDGTGNATITNIDQRLVQSSAVDSLRRELGLSEEDTSIIEPFVEVRELEPNVTLITEGNAEDVCIWFVMTGTLAVYQSNADATRAAKQDSKNDMLIHFVHPGEIVGGLAMLTGEASAYTIRARSNSRIAYIRRAAIYQIMRQRPRIVLDLGNGVVRRLSPLVRQCDYALDWIFLESGRAVYRQDESSDSTYIVLSGRMRSVITHPGGKKEIVGEYGKGDLVGIVEMITETSRTTTVLAVRDSELAKLPEGLFNAIKLRYPIVVTRLISFLSHRFLGSMQTRGANASSAPVEANPVTHKYSTVALVPITDDVPITPFTYELYHSLCAIGPVLRLTSEVVRKQLGNNIFEAANEYRLTSWLAQQEDRNIITLYQCDSALSPWTQRCMRQADVVLIVGLGERSHMVGKFEREIDKLAMRTQKELVLLYPETTNARPANTLSWLNARPWVTKHHHVLCVKRIFTRKSQYRINDLYSRVLLSEPNMHSDFSRLARWLTGNSIGLVLGGGGARGAAHIGMLKAIQEAGIPIDMVGGVSIGALMGALWCSERNITTVTQKAREWSKKMTKWFLQLLDLTYPITSMFSGREFNKTIHDTFGDVSIEDLWIPYFTLTTDITASCHRIHTNGSLWRYVRSSMSLSGYMPPLCDPQDGHLLLDGGYVNNLPGHLWRYCRASMSIAGVFPPFCDYRDGHLLLDGCYTNNVPADVMHNLGAAHIIAIDVGSQDDTDLTNYGDDLSGWWLLYKKWNPFTSPVKVPDLPDIQSRLAYVSCVRQLEEVKNSDYCEYIRPPIDKYKTLAFGSFDEIRDVGYVFGKNYFDNMAKAGRLGRFNQWFNKEPPKRGNHASLNEYTFIDLAQIVCKLPETYALNAVDIFSEDEDFDGYISEPTTLNMDRHRIQVPRAGNSLSFSETELDSDVEIDLELERKVDKSTQSTPPTPNKKHPSTPTSSQGNLMHLPLSMKAKDKMQILDKLEREHKRRQKSKHKRDRSMQRDSKATLHPAPMAEATTQTPSSDVDIDAKLDQLRKLQQELEQGNESEQEQEQEQEQEQGHIQEPENVTEADTKN |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000389223 | 1-1488 | Neuropathy target esterase sws | |||
Sequence: MDVLELLRASVNGCYNTLFSDAWSQYVSKQIATTTYWYGALLAIGALFIAWFLYFKRLASLRLRDESARTLSALTAASGGDHRGLRFRKRDKMLFYGRRMLRKMKNVSGQMYSSGKGYKRRAVMRFARRILQLQRENRPLEMKTVEPPAEYLEETIDGSDRVPPDALYMLQSIRIFGHFEKPIFLKLCKHTQLLQLMAGDYLFKITDPDDSVYIVQSGMINVYICNADGSTLSLKTVRKGESVTSLLSFIDVLSGNSSYYKTVTAKAMEKSVVIRLPMQAFEEVFNENPDVMIRVIQVIMIRLQRVLFTALRNYLGLNAELVQNHMRIKGSNPVPVTVPGPVLSQASQASRAMASRPATSPVTRMSREEHTLSDPDPNPNASAMLFAEVHGDAPYIDLYHHQQQQSSGVSVGGTHRSSGACTPTGSGGESPDGTGNATITNIDQRLVQSSAVDSLRRELGLSEEDTSIIEPFVEVRELEPNVTLITEGNAEDVCIWFVMTGTLAVYQSNADATRAAKQDSKNDMLIHFVHPGEIVGGLAMLTGEASAYTIRARSNSRIAYIRRAAIYQIMRQRPRIVLDLGNGVVRRLSPLVRQCDYALDWIFLESGRAVYRQDESSDSTYIVLSGRMRSVITHPGGKKEIVGEYGKGDLVGIVEMITETSRTTTVLAVRDSELAKLPEGLFNAIKLRYPIVVTRLISFLSHRFLGSMQTRGANASSAPVEANPVTHKYSTVALVPITDDVPITPFTYELYHSLCAIGPVLRLTSEVVRKQLGNNIFEAANEYRLTSWLAQQEDRNIITLYQCDSALSPWTQRCMRQADVVLIVGLGERSHMVGKFEREIDKLAMRTQKELVLLYPETTNARPANTLSWLNARPWVTKHHHVLCVKRIFTRKSQYRINDLYSRVLLSEPNMHSDFSRLARWLTGNSIGLVLGGGGARGAAHIGMLKAIQEAGIPIDMVGGVSIGALMGALWCSERNITTVTQKAREWSKKMTKWFLQLLDLTYPITSMFSGREFNKTIHDTFGDVSIEDLWIPYFTLTTDITASCHRIHTNGSLWRYVRSSMSLSGYMPPLCDPQDGHLLLDGGYVNNLPGHLWRYCRASMSIAGVFPPFCDYRDGHLLLDGCYTNNVPADVMHNLGAAHIIAIDVGSQDDTDLTNYGDDLSGWWLLYKKWNPFTSPVKVPDLPDIQSRLAYVSCVRQLEEVKNSDYCEYIRPPIDKYKTLAFGSFDEIRDVGYVFGKNYFDNMAKAGRLGRFNQWFNKEPPKRGNHASLNEYTFIDLAQIVCKLPETYALNAVDIFSEDEDFDGYISEPTTLNMDRHRIQVPRAGNSLSFSETELDSDVEIDLELERKVDKSTQSTPPTPNKKHPSTPTSSQGNLMHLPLSMKAKDKMQILDKLEREHKRRQKSKHKRDRSMQRDSKATLHPAPMAEATTQTPSSDVDIDAKLDQLRKLQQELEQGNESEQEQEQEQEQEQGHIQEPENVTEADTKN | ||||||
Modified residue | 1176 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Interaction
Subunit
Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws.
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 339-379 | Disordered | ||||
Sequence: PGPVLSQASQASRAMASRPATSPVTRMSREEHTLSDPDPNP | ||||||
Compositional bias | 341-366 | Polar residues | ||||
Sequence: PVLSQASQASRAMASRPATSPVTRMS | ||||||
Region | 402-440 | Disordered | ||||
Sequence: QQQQSSGVSVGGTHRSSGACTPTGSGGESPDGTGNATIT | ||||||
Domain | 929-1095 | PNPLA | ||||
Sequence: LVLGGGGARGAAHIGMLKAIQEAGIPIDMVGGVSIGALMGALWCSERNITTVTQKAREWSKKMTKWFLQLLDLTYPITSMFSGREFNKTIHDTFGDVSIEDLWIPYFTLTTDITASCHRIHTNGSLWRYVRSSMSLSGYMPPLCDPQDGHLLLDGGYVNNLPGHLWR | ||||||
Motif | 933-938 | GXGXXG | ||||
Sequence: GGGARG | ||||||
Motif | 960-964 | GXSXG | ||||
Sequence: GVSIG | ||||||
Motif | 1082-1084 | DGA/G | ||||
Sequence: DGG | ||||||
Region | 1348-1376 | Disordered | ||||
Sequence: RKVDKSTQSTPPTPNKKHPSTPTSSQGNL | ||||||
Compositional bias | 1353-1376 | Polar residues | ||||
Sequence: STQSTPPTPNKKHPSTPTSSQGNL | ||||||
Region | 1398-1488 | Disordered | ||||
Sequence: EHKRRQKSKHKRDRSMQRDSKATLHPAPMAEATTQTPSSDVDIDAKLDQLRKLQQELEQGNESEQEQEQEQEQEQGHIQEPENVTEADTKN | ||||||
Compositional bias | 1441-1456 | Basic and acidic residues | ||||
Sequence: DAKLDQLRKLQQELEQ | ||||||
Compositional bias | 1467-1488 | Basic and acidic residues | ||||
Sequence: EQEQEQGHIQEPENVTEADTKN |
Sequence similarities
Belongs to the NTE family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,488
- Mass (Da)167,474
- Last updated2008-09-23 v1
- Checksum9118C9BA05DC5A56
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 341-366 | Polar residues | ||||
Sequence: PVLSQASQASRAMASRPATSPVTRMS | ||||||
Compositional bias | 1353-1376 | Polar residues | ||||
Sequence: STQSTPPTPNKKHPSTPTSSQGNL | ||||||
Compositional bias | 1441-1456 | Basic and acidic residues | ||||
Sequence: DAKLDQLRKLQQELEQ | ||||||
Compositional bias | 1467-1488 | Basic and acidic residues | ||||
Sequence: EQEQEQGHIQEPENVTEADTKN |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CH933811 EMBL· GenBank· DDBJ | EDW06294.1 EMBL· GenBank· DDBJ | Genomic DNA |