B4L535 · SWS_DROMO

Function

function

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain (By similarity).

Catalytic activity

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site175-302a nucleoside 3',5'-cyclic phosphate 1 (UniProtKB | ChEBI)
Binding site458-587a nucleoside 3',5'-cyclic phosphate 2 (UniProtKB | ChEBI)
Binding site576-703a nucleoside 3',5'-cyclic phosphate 3 (UniProtKB | ChEBI)
Active site962Nucleophile
Active site1082Proton acceptor

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentplasma membrane
Molecular Functionlysophospholipase activity
Molecular Functionprotein kinase A catalytic subunit binding
Biological Processensheathment of neurons
Biological Processglial cell apoptotic process
Biological Processlipid catabolic process
Biological Processmembrane lipid metabolic process
Biological Processmembrane organization
Biological Processneuron apoptotic process
Biological Processphosphatidylcholine metabolic process
Biological Processphotoreceptor cell maintenance
Biological Processprotein localization to membrane
Biological Processsensory perception of smell

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Neuropathy target esterase sws
  • Alternative names

Gene names

    • Name
      sws
    • ORF names
      GI21654

Organism names

  • Taxonomic identifier
  • Strain
    • Tucson 15081-1352.22
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila

Accessions

  • Primary accession
    B4L535

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass type I membrane protein
Note: Sws tethers Pka-C3 to the membrane.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-34Lumenal
Transmembrane35-55Helical
Topological domain56-1488Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00003892231-1488Neuropathy target esterase sws
Modified residue1176Phosphoserine

Keywords

Interaction

Subunit

Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws.

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain, motif.

TypeIDPosition(s)Description
Region339-379Disordered
Compositional bias341-366Polar residues
Region402-440Disordered
Domain929-1095PNPLA
Motif933-938GXGXXG
Motif960-964GXSXG
Motif1082-1084DGA/G
Region1348-1376Disordered
Compositional bias1353-1376Polar residues
Region1398-1488Disordered
Compositional bias1441-1456Basic and acidic residues
Compositional bias1467-1488Basic and acidic residues

Sequence similarities

Belongs to the NTE family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,488
  • Mass (Da)
    167,474
  • Last updated
    2008-09-23 v1
  • Checksum
    9118C9BA05DC5A56
MDVLELLRASVNGCYNTLFSDAWSQYVSKQIATTTYWYGALLAIGALFIAWFLYFKRLASLRLRDESARTLSALTAASGGDHRGLRFRKRDKMLFYGRRMLRKMKNVSGQMYSSGKGYKRRAVMRFARRILQLQRENRPLEMKTVEPPAEYLEETIDGSDRVPPDALYMLQSIRIFGHFEKPIFLKLCKHTQLLQLMAGDYLFKITDPDDSVYIVQSGMINVYICNADGSTLSLKTVRKGESVTSLLSFIDVLSGNSSYYKTVTAKAMEKSVVIRLPMQAFEEVFNENPDVMIRVIQVIMIRLQRVLFTALRNYLGLNAELVQNHMRIKGSNPVPVTVPGPVLSQASQASRAMASRPATSPVTRMSREEHTLSDPDPNPNASAMLFAEVHGDAPYIDLYHHQQQQSSGVSVGGTHRSSGACTPTGSGGESPDGTGNATITNIDQRLVQSSAVDSLRRELGLSEEDTSIIEPFVEVRELEPNVTLITEGNAEDVCIWFVMTGTLAVYQSNADATRAAKQDSKNDMLIHFVHPGEIVGGLAMLTGEASAYTIRARSNSRIAYIRRAAIYQIMRQRPRIVLDLGNGVVRRLSPLVRQCDYALDWIFLESGRAVYRQDESSDSTYIVLSGRMRSVITHPGGKKEIVGEYGKGDLVGIVEMITETSRTTTVLAVRDSELAKLPEGLFNAIKLRYPIVVTRLISFLSHRFLGSMQTRGANASSAPVEANPVTHKYSTVALVPITDDVPITPFTYELYHSLCAIGPVLRLTSEVVRKQLGNNIFEAANEYRLTSWLAQQEDRNIITLYQCDSALSPWTQRCMRQADVVLIVGLGERSHMVGKFEREIDKLAMRTQKELVLLYPETTNARPANTLSWLNARPWVTKHHHVLCVKRIFTRKSQYRINDLYSRVLLSEPNMHSDFSRLARWLTGNSIGLVLGGGGARGAAHIGMLKAIQEAGIPIDMVGGVSIGALMGALWCSERNITTVTQKAREWSKKMTKWFLQLLDLTYPITSMFSGREFNKTIHDTFGDVSIEDLWIPYFTLTTDITASCHRIHTNGSLWRYVRSSMSLSGYMPPLCDPQDGHLLLDGGYVNNLPGHLWRYCRASMSIAGVFPPFCDYRDGHLLLDGCYTNNVPADVMHNLGAAHIIAIDVGSQDDTDLTNYGDDLSGWWLLYKKWNPFTSPVKVPDLPDIQSRLAYVSCVRQLEEVKNSDYCEYIRPPIDKYKTLAFGSFDEIRDVGYVFGKNYFDNMAKAGRLGRFNQWFNKEPPKRGNHASLNEYTFIDLAQIVCKLPETYALNAVDIFSEDEDFDGYISEPTTLNMDRHRIQVPRAGNSLSFSETELDSDVEIDLELERKVDKSTQSTPPTPNKKHPSTPTSSQGNLMHLPLSMKAKDKMQILDKLEREHKRRQKSKHKRDRSMQRDSKATLHPAPMAEATTQTPSSDVDIDAKLDQLRKLQQELEQGNESEQEQEQEQEQEQGHIQEPENVTEADTKN

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias341-366Polar residues
Compositional bias1353-1376Polar residues
Compositional bias1441-1456Basic and acidic residues
Compositional bias1467-1488Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH933811
EMBL· GenBank· DDBJ
EDW06294.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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