B4KRD9 · B4KRD9_DROMO
- ProteinReceptor protein-tyrosine kinase
- GeneDmoj\GI19081
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1430 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
Features
Showing features for binding site, active site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameReceptor protein-tyrosine kinase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila
Accessions
- Primary accessionB4KRD9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 872-895 | Helical | ||||
Sequence: MIIIIFVAVFIPVICVLSVIIYIC |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-34 | |||||
Sequence: MRIFKLFRRRGSSFYLPLLLLLLVHCICMWPVLA | ||||||
Chain | PRO_5002811290 | 35-1430 | Receptor protein-tyrosine kinase | |||
Sequence: ARDRFARQNSKQRHQDAYRNNASRARNRGGGSGNHERAAAAAAAASSAALIASGSSIGDNNKDTFPKGKICIGTKSRLSVPSNREHHYRNLRDRYTNCTYVDGNLELTWLQDPNLDLSFLANIREVTGYILISHVDVTNVIFPKLQIIRGRTLFSLTVEEEKYALFATYSKMNTLEMPELRDILAGWVGFFNNYNLCHTRSIVWREILSGANDDYNYTYTFTAAERTCPACHPSCERGACWGEGAHNCQKFSKITCAPQCAQGRCFGSGPRDCCHLFCAGGCTGPTQKDCIACKNFFDDGVCKEECPPMRKYNPTNYELEANPEGKYAYGATCVRECPGHLLKDNGACVRSCPSDKMAKDGECVACNGPCPKTCPGVAVLHSGNIDSFKNCTVIEGNIRVLDQTFSGYQDIYANYTMGARYIPMHPDRLEVFSTVKEITGYLNIEGVHPQFKNLSYFRNLEVIHGRQLMESYFAALAIVKSSLSSLELRSLKRINSGSIVIQHNTQLCYVSSIHWAAIQKTNDQKLFINENLNTSECRKTGQICSDQCNSDGCWGAGPEQCLNCKSFNYNGTCIADCRNVSNTYQFDSKTCKKCHPECRTCSGPGAEHCDECVHVRDEQHCVTVCPDDKYADFGICRKCHETCEGCTGPKNTIGHGACNTCNLAIINADATVERCLRKDDKCPDGYYWEYVHPQEQGSLKPLAGKAICRKCHPRCELCTNYGFHLQVCSKCARYKRLEQCEDECPSDHYADEERRECFVCHPECKGCTGPGAEDCLACVNFKVFAEGEVYDNSTMFNCTSKCPAEQPHVNYQSHFIGPHCVSSPPRGSKVTANLNVNMIIIIFVAVFIPVICVLSVIIYICRQKQQEKKETDDLAKAFFGCDDAEPLRPSNIGANLSKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKTSGAESSQEFLNEAYAMATVEHGNLLKLLAVCMSSQMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEERRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSLESNEYKAAGGKMPIKWLALECIRHRIFSSKSDVWAFGVTIWELLTFGQRPHENILAKDIPDLIEMGLKLEQPEICSLDIYCTLLSCWQLDADLRPTFKQLTNVFAEFARDPGRFLVIPGDKFTRLPAYTSQDEKDLIRKLAPTTDGSEPLVEADDYLQPKAAPGPSHRTDGTDEIPKLNRYCKDPSNKNSNSGGGVGDDETDSNAREVGVGNLRLDLPVDEDDYLMPTGQSNGSNNNNNNSNNPNNNMAAAATGYIDVIGVPVSVDNPEYLLNALSAGEAPIPTQTIGIPVAGVPGSMEVKMPGSESTSSDHEYYNDTQRELQPLQLLRSRSTETRV |
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 44-71 | Disordered | ||||
Sequence: SKQRHQDAYRNNASRARNRGGGSGNHER | ||||||
Domain | 941-1201 | Protein kinase | ||||
Sequence: LRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKTSGAESSQEFLNEAYAMATVEHGNLLKLLAVCMSSQMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEERRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSLESNEYKAAGGKMPIKWLALECIRHRIFSSKSDVWAFGVTIWELLTFGQRPHENILAKDIPDLIEMGLKLEQPEICSLDIYCTLLSCWQLDADLRPTFKQLTNVFAEFA | ||||||
Region | 1249-1339 | Disordered | ||||
Sequence: YLQPKAAPGPSHRTDGTDEIPKLNRYCKDPSNKNSNSGGGVGDDETDSNAREVGVGNLRLDLPVDEDDYLMPTGQSNGSNNNNNNSNNPNN | ||||||
Compositional bias | 1276-1291 | Polar residues | ||||
Sequence: KDPSNKNSNSGGGVGD | ||||||
Compositional bias | 1320-1339 | Polar residues | ||||
Sequence: PTGQSNGSNNNNNNSNNPNN | ||||||
Region | 1394-1430 | Disordered | ||||
Sequence: KMPGSESTSSDHEYYNDTQRELQPLQLLRSRSTETRV | ||||||
Compositional bias | 1412-1430 | Polar residues | ||||
Sequence: QRELQPLQLLRSRSTETRV |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,430
- Mass (Da)158,787
- Last updated2008-09-23 v1
- Checksum49C03108E0588C1F
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0Q9X8X6 | A0A0Q9X8X6_DROMO | Dmoj\GI19081 | 1369 | ||
B4LAM3 | B4LAM3_DROMO | Dmoj\GI11284 | 129 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1276-1291 | Polar residues | ||||
Sequence: KDPSNKNSNSGGGVGD | ||||||
Compositional bias | 1320-1339 | Polar residues | ||||
Sequence: PTGQSNGSNNNNNNSNNPNN | ||||||
Compositional bias | 1412-1430 | Polar residues | ||||
Sequence: QRELQPLQLLRSRSTETRV |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CH933808 EMBL· GenBank· DDBJ | EDW09355.1 EMBL· GenBank· DDBJ | Genomic DNA |