B4KFE1 · AFFL_DROMO

Function

function

Has a role in transcriptional regulation. Acts in parallel with the Ras/MAPK and the PI3K/PKB pathways in the control of cell identity and cellular growth. Essential for regulation of the cytoskeleton and cell growth but not for cell proliferation or growth rate. Required specifically for the microtubule-based basal transport of lipid droplets. Plays a partially redundant function downstream of Raf in cell fate specification in the developing eye. Pair-rule protein that regulates embryonic cellularization, gastrulation and segmentation (By similarity).

Features

Showing features for dna binding.

117822004006008001,0001,2001,4001,600
TypeIDPosition(s)Description
DNA binding920-932A.T hook

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular Functiontranscription coregulator activity
Biological Processperiodic partitioning by pair rule gene
Biological Processregulation of cytoskeleton organization
Biological Processregulation of DNA-templated transcription
Biological Processregulation of lipid transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    AF4/FMR2 family member lilli
  • Alternative names
    • Protein lilliputian

Gene names

    • Name
      lilli
    • ORF names
      GI11857

Organism names

  • Taxonomic identifier
  • Strain
    • Tucson 15081-1352.22
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila

Accessions

  • Primary accession
    B4KFE1

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00003946761-1782AF4/FMR2 family member lilli
Modified residue443Phosphothreonine
Modified residue472Phosphoserine
Modified residue474Phosphoserine
Modified residue878Phosphoserine
Modified residue879Phosphoserine
Modified residue949Phosphoserine
Modified residue951Phosphoserine
Modified residue1457Phosphoserine

Keywords

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region42-84Disordered
Compositional bias43-74Basic and acidic residues
Compositional bias150-186Polar residues
Region150-313Disordered
Compositional bias219-273Polar residues
Region434-515Disordered
Compositional bias452-484Basic and acidic residues
Compositional bias485-515Polar residues
Region605-637Disordered
Region691-732Disordered
Compositional bias714-732Polar residues
Region768-820Disordered
Compositional bias780-805Polar residues
Region839-891Disordered
Region911-1064Disordered
Compositional bias928-961Polar residues
Compositional bias970-1011Polar residues
Compositional bias1029-1053Polar residues
Region1091-1126Disordered
Compositional bias1166-1196Polar residues
Region1166-1234Disordered
Region1296-1327Disordered
Region1386-1420Disordered
Compositional bias1387-1420Basic and acidic residues
Region1450-1484Disordered
Compositional bias1674-1700Polar residues
Region1674-1701Disordered

Sequence similarities

Belongs to the AF4 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,782
  • Mass (Da)
    191,052
  • Last updated
    2008-09-23 v1
  • Checksum
    3A0FF5ECAC87E46C
MAQQQQQQHQQQQHHQQQQQLLLQQQQQLLQYNNNLYNLNYNMEDNERRKRREREKYERQQGIQSDDRETSLFGEPRRLNPSEGDAEITAALGEFIDARDHMNSSTVGIYRHASTNASSSRLPALSFGGSSLANSYSTSSASVNPAASLASSSASVPGQLPTSQQQQQQQQQQQHYQQQQRAPTYLKQADNKPPYNGRGGYPGQPMKNDIPSSSGMAPPRGPPRSSSSASQSNSNSNSINSSSATNNATSGATSASMSSPLGPPLSTQMPNGREKSFLGPPAPALPNGGRFVPPAASSKRPSNSVGLQPPPPEKDISKIITEMTNNYRVTPLTSIAATPHAPMSENYNLNGPNKFKYAFDSIGPLNSPPAAGASSLMTPLLAPIAPITSPIAPLLTTPPQASQLPLPLAPLAGATTVPPALGGMAAVAPIQQLMPTPPKASPTPPAIKPMKTEKNHSLEKQDSCLENDLELSESDDERKKEGRSAGNSSNSSESDSSESGSEASSKGDTQQQQQQQQQQQQQQLLLQQQQQQQLLLQQQQQRLAASANGSKKKYSQTIIASGANTISGLLTSSGLGGAGAGSVAGGAGGAGGAINATNNTCGGGGGSSGSCMGTMSSSSSSNKTPSPTDSNRWNLSRFFPKPANQTAAESVSPGVANAIGNVSMKVPGILPGGAQIIPESIDVTTAIVKNEKLHDEPRHVGDDEDDEADEQHRQQQQQQQQQQQQQQQQQRYGLSVTVKKEQLEQQQQQQLLLQQQQQLTTEQLALAGALPKNQIKRESRLSDSGSASSGSGSGSSSSDSAGGSSEVLQMPGPGETLQIPGVPAAITTVLRVPQAMQHKVQPNSVTLTPIGPLPASPKPRQKKPRKKKMSAATAPLDSSDEDEPTASSNKKHALELAATAAAAAAAVAVPVAAAAAPAIKKGRGRPRKQAQQQQQQQQQQLQQSGNLSSASASSSQAKGPTLTAAKKPLAKASVSNSNSTAPATVAAGTRKREHSSNSSSNSNTPTKKPTATFATMAAKLDRADALSSDDDSSSSSSCSSTKSSSSSGSDSETPAAAAAGAAASTATTVVTTSAQNPAKKRIVKINKVGVAGNSSSSSKAKRRYSVGSSSNSSSSSETEEQQQHKQQQLLLLQQQQQKQQLQHQQQLQQQQQQQQSLLGQFAAESLPQSAQRLSSSDCSSSSNSDSSSNSSGSSSSSDEDGEHRSGKRKSDKKKICTLTRIFNPKEGGAKKQGQVVIIDQSEEQQQQQQQQQQQAKELKPRATPTQLLGATLASPARTTTPHLTSLMCKIDLSKLARQHHHQPERLKAQQNGHLSSRSAEGARTPKDLQQICTPNGYVGGAAGGGAAASKLLGGVKHEHGVKPEPELEPGYEGKYKLNSVKQEFMLKQELPARRRKRSSSSSSSPYKEKKRKKEKAEQLSKELLPVPVLLPANNHERLSRDKLELLMQQQESAANGSPNKLQQQQQQSRLSQSQQQQQQQQQQQSLSQSTTAAATVAAAPIQLPTTCSEAVQTTPPPAAPQPEPRLIYRSHFDKEEENENDDLRKNDFLLQEAIRRKRAADSERDSFSQMTLYLEAIVYFLLTADAMERCNMEATWTMYKDTLSLIKYISSKNRPYQLSTNGNHESHNIVAILSLRCQSLISLKLYKLRRVNCRAIIASCTEFFRSGRGDILNGNTPSSISPSNSVGSQGSGSNTPPGKIVPQDIHNMLCKQNEYLTYVNSAHELWDQADRLVRNGNHIDFIRKLDHENGPLTLHSTMHEVFRYVQAGLKTLRDAVSYPQSQ

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias43-74Basic and acidic residues
Compositional bias150-186Polar residues
Compositional bias219-273Polar residues
Compositional bias452-484Basic and acidic residues
Compositional bias485-515Polar residues
Compositional bias714-732Polar residues
Compositional bias780-805Polar residues
Compositional bias928-961Polar residues
Compositional bias970-1011Polar residues
Compositional bias1029-1053Polar residues
Compositional bias1166-1196Polar residues
Compositional bias1387-1420Basic and acidic residues
Compositional bias1674-1700Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH933807
EMBL· GenBank· DDBJ
EDW12041.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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