B4JG93 · B4JG93_DROGR

Function

function

Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.

Catalytic activity

  • n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.
    EC:5.6.1.1 (UniProtKB | ENZYME | Rhea)

Activity regulation

ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.

Features

Showing features for binding site.

160750100150200250300350400450500550600
TypeIDPosition(s)Description
Binding site368-375ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcentrosome
Cellular Componentcytoplasm
Cellular Componentmicrotubule
Cellular Componentspindle pole
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionisomerase activity
Molecular Functionmicrotubule binding
Molecular Functionmicrotubule severing ATPase activity
Biological Processcell division
Biological Processmicrotubule severing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Katanin p60 ATPase-containing subunit A1
  • EC number
  • Short names
    Katanin p60 subunit A1
  • Alternative names
    • p60 katanin

Gene names

    • Name
      KATNA1
    • Synonyms
      Dgri\GH18155
    • ORF names
      Dgri_GH18155

Organism names

  • Taxonomic identifier
  • Strain
    • Tucson 15287-2541.00
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Hawaiian Drosophila

Accessions

  • Primary accession
    B4JG93

Proteomes

Subcellular Location

Cytoplasm, cytoskeleton
Cytoplasm
Note: Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1.

Keywords

Interaction

Subunit

Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias76-100Polar residues
Region76-206Disordered
Compositional bias137-164Polar residues
Compositional bias177-206Polar residues
Region223-297Disordered
Compositional bias241-255Polar residues
Compositional bias266-292Polar residues
Domain360-499AAA+ ATPase

Sequence similarities

Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    607
  • Mass (Da)
    67,371
  • Last updated
    2008-09-23 v1
  • Checksum
    D2531E46DA9D9877
MRGEETYRRTTREKIVLRGNTTIRTVDSTSTYLPMMSAGSSTPPTNLSHMARMMDSLILDSLSPFAFTKITATSRPARNTNAVKKPSAESVHQNQQHPHIAAANPHPHRPVNNLGANAPNGLGIGGALPLRSKQRLPTQEVAPQPRSSQPAMPFPSQQQQDSRWVSSLRRRDPELQPTLPSINSNLNSNSLSQSHHGSAGNVGMATNSTASVGLRLGRPGRASALTTAVRKSRSVERLRARKLSTSTQLTLKQRAVKKNSLDENSNSDDQDATTSLEDNSHTQSTTHNTPRCSPKTKVKHFSPLGYEGHLVDTLEKDILQRHPCIKWTDVAGLNEAKTILQEAVVLPIIMPEFFKGIRRPWRGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPSTIFIDEIDALCASRGSDSEHEASRRFKAELLIQMDGLNASLQDEKVIMVLAATNHPWDIDEAFRRRFEKRIYIPLPNDETRSALLELCLKDVSLSSDLNTRMIGDELQGYSGSDISNVCRDASMMAMRRLISGRTPQQIKQIRREDADQPITLQDFLDAQQRTKKSVSADDVARFEKWMEEYGSC

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias76-100Polar residues
Compositional bias137-164Polar residues
Compositional bias177-206Polar residues
Compositional bias241-255Polar residues
Compositional bias266-292Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH916369
EMBL· GenBank· DDBJ
EDV93660.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp