B4J780 · LPHN_DROGR
- ProteinLatrophilin Cirl
- GeneCirl
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1777 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Features
Showing features for site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 760-761 | Cleavage; by autolysis | |||
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | carbohydrate binding | |
Molecular Function | G protein-coupled receptor activity | |
Molecular Function | mechanoreceptor activity | |
Biological Process | adenylate cyclase-activating G protein-coupled receptor signaling pathway | |
Biological Process | adult locomotory behavior | |
Biological Process | cell surface receptor signaling pathway | |
Biological Process | proprioception |
Keywords
- Molecular function
- Ligand
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameLatrophilin Cirl
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Hawaiian Drosophila
Accessions
- Primary accessionB4J780
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Topological domain | 1-786 | Extracellular | |||
Transmembrane | 787-807 | Helical; Name=1 | |||
Topological domain | 808-820 | Cytoplasmic | |||
Transmembrane | 821-841 | Helical; Name=2 | |||
Topological domain | 842-847 | Extracellular | |||
Transmembrane | 848-868 | Helical; Name=3 | |||
Topological domain | 869-894 | Cytoplasmic | |||
Transmembrane | 895-915 | Helical; Name=4 | |||
Topological domain | 916-940 | Extracellular | |||
Transmembrane | 941-961 | Helical; Name=5 | |||
Topological domain | 962-988 | Cytoplasmic | |||
Transmembrane | 989-1009 | Helical; Name=6 | |||
Topological domain | 1010-1016 | Extracellular | |||
Transmembrane | 1017-1037 | Helical; Name=7 | |||
Topological domain | 1038-1777 | Cytoplasmic | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000393374 | 1-1777 | Latrophilin Cirl | ||
Glycosylation | 5 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 162 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 257 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 300 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 351 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 415 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 674 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 722 | N-linked (GlcNAc...) asparagine | |||
Disulfide bond | 728↔755 | ||||
Disulfide bond | 743↔757 | ||||
Glycosylation | 749 | N-linked (GlcNAc...) asparagine | |||
Modified residue | 1189 | Phosphoserine | |||
Modified residue | 1289 | Phosphoserine | |||
Modified residue | 1296 | Phosphoserine | |||
Modified residue | 1366 | Phosphoserine | |||
Modified residue | 1367 | Phosphoserine | |||
Post-translational modification
Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.
Keywords
- PTM
PTM databases
Interaction
Subunit
Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 45-134 | SUEL-type lectin | |||
Region | 189-304 | Disordered | |||
Compositional bias | 223-246 | Basic and acidic residues | |||
Compositional bias | 247-269 | Polar residues | |||
Compositional bias | 278-304 | Polar residues | |||
Domain | 580-773 | GAIN-B | |||
Region | 728-773 | GPS | |||
Region | 1096-1127 | Disordered | |||
Compositional bias | 1105-1125 | Basic and acidic residues | |||
Region | 1235-1257 | Disordered | |||
Region | 1270-1300 | Disordered | |||
Region | 1344-1369 | Disordered | |||
Region | 1511-1596 | Disordered | |||
Compositional bias | 1516-1536 | Polar residues | |||
Compositional bias | 1545-1562 | Acidic residues | |||
Region | 1684-1756 | Disordered | |||
Compositional bias | 1700-1756 | Polar residues | |||
Sequence similarities
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusComplete
- Length1,777
- Mass (Da)194,170
- Last updated2008-09-23 v1
- ChecksumC82E7FDE4C4B8918
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 223-246 | Basic and acidic residues | |||
Compositional bias | 247-269 | Polar residues | |||
Compositional bias | 278-304 | Polar residues | |||
Compositional bias | 1105-1125 | Basic and acidic residues | |||
Compositional bias | 1516-1536 | Polar residues | |||
Compositional bias | 1545-1562 | Acidic residues | |||
Compositional bias | 1700-1756 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CH916367 EMBL· GenBank· DDBJ | EDW02098.1 EMBL· GenBank· DDBJ | Genomic DNA |