B4J780 · LPHN_DROGR

Function

Features

Showing features for site.

117772004006008001,0001,2001,4001,600
TypeIDPosition(s)Description
Site760-761Cleavage; by autolysis

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functioncarbohydrate binding
Molecular FunctionG protein-coupled receptor activity
Molecular Functionmechanoreceptor activity
Biological Processadenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Processadult locomotory behavior
Biological Processcell surface receptor signaling pathway
Biological Processproprioception

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Latrophilin Cirl

Gene names

    • Name
      Cirl
    • ORF names
      GH20083

Organism names

  • Taxonomic identifier
  • Strain
    • Tucson 15287-2541.00
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Hawaiian Drosophila

Accessions

  • Primary accession
    B4J780

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1-786Extracellular
Transmembrane787-807Helical; Name=1
Topological domain808-820Cytoplasmic
Transmembrane821-841Helical; Name=2
Topological domain842-847Extracellular
Transmembrane848-868Helical; Name=3
Topological domain869-894Cytoplasmic
Transmembrane895-915Helical; Name=4
Topological domain916-940Extracellular
Transmembrane941-961Helical; Name=5
Topological domain962-988Cytoplasmic
Transmembrane989-1009Helical; Name=6
Topological domain1010-1016Extracellular
Transmembrane1017-1037Helical; Name=7
Topological domain1038-1777Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond, modified residue.

Type
IDPosition(s)Description
ChainPRO_00003933741-1777Latrophilin Cirl
Glycosylation5N-linked (GlcNAc...) asparagine
Glycosylation162N-linked (GlcNAc...) asparagine
Glycosylation257N-linked (GlcNAc...) asparagine
Glycosylation300N-linked (GlcNAc...) asparagine
Glycosylation351N-linked (GlcNAc...) asparagine
Glycosylation415N-linked (GlcNAc...) asparagine
Glycosylation674N-linked (GlcNAc...) asparagine
Glycosylation722N-linked (GlcNAc...) asparagine
Disulfide bond728↔755
Disulfide bond743↔757
Glycosylation749N-linked (GlcNAc...) asparagine
Modified residue1189Phosphoserine
Modified residue1289Phosphoserine
Modified residue1296Phosphoserine
Modified residue1366Phosphoserine
Modified residue1367Phosphoserine

Post-translational modification

Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.

Keywords

PTM databases

Interaction

Subunit

Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain45-134SUEL-type lectin
Region189-304Disordered
Compositional bias223-246Basic and acidic residues
Compositional bias247-269Polar residues
Compositional bias278-304Polar residues
Domain580-773GAIN-B
Region728-773GPS
Region1096-1127Disordered
Compositional bias1105-1125Basic and acidic residues
Region1235-1257Disordered
Region1270-1300Disordered
Region1344-1369Disordered
Region1511-1596Disordered
Compositional bias1516-1536Polar residues
Compositional bias1545-1562Acidic residues
Region1684-1756Disordered
Compositional bias1700-1756Polar residues

Sequence similarities

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    1,777
  • Mass (Da)
    194,170
  • Last updated
    2008-09-23 v1
  • Checksum
    C82E7FDE4C4B8918
MYLKNHTLGLRTKASQGAPLAKAAQSLLQLKKLDCVPPKYQTAYACEGKKLTIECEPGDLINLIRANYGRFSITICNDHGNVEWSVNCMFPKSLTVLNSKCSHKQSCSVLAATSMFGDPCPGTHKYLEAHYQCISAAQTSTTTNRPSPPPWVLSNGPPIFGNGSGLIQPTPQPPPRLPTLPGVVGIHGINGVPPTHATPSSSTAMLPGGRLKGVTSATTKHPGGRHDGLRPPPQLHHHHHHTDDTAPTKSSSGSAGNVTAPSNTRILTGVGGGGSDDGTLLTTKSSPNRTPGTAASAANNNSLGIGGTAPGSGGGVVRTINNINLNAAGMGAEDESKLFCGPTHARNLFWNMTRVGDVNVQPCPGGAAGIAKWRCVLMKRVPDAGYDEYDDEMPVASSTTPMPPPSSAGGDCLHNSSSCEPPVSMAHKVNQNQRLRNFEPTWHPLTPDLTQCRSLWLNSLEMRVNQQDSSLISIANDLSEVTSSKTLYGGDMLVTTKIIQRMSEKMLHDKGTFPDQRQREAIIMELLHGVVKTGSNLLDESQLSSWLDLNQEDQMRVATSLLTGLEYNAFLLADTIIRERNVVQKVKNILLSVRVLETKTIQGNVVFPDSDQWPLSSDRIELPRTALKENSEGGLVRIVFAAFDRLESILKPSYDHFDLKSARSYVRNTAILSNDSDTNAGEMQQRVRILNSKVISASLGKGRHIQLSQPIKLVLKHLKTENVSNPTCVFWNYIDHAWSANGCSLESTNRTHSVCSCNHLTNFAILMDVVDEHQHSLFTMFDGNMRIFIYISVAICVVFIIIALLTLKLFNGVFVKSARTSIYSSIYICLLAIELLFLLGIEQTETSIFCGFITVFLHCAILSGTAWFCYEAFHSYSTLTSDELLLEVDQTPKVNCYYLLSYGLSLSVVAISLGINPSTYTLRNDYCVLMEANALFYVTFVAPILIFFVAAISYTFLSWIIMRRKSRTALKTKEHTRLANVRFDIRCSFVFLLLLSADWCCAYFYLRGAKLDEDVAAIYGYCFVCFNTLMGLYIFVFHCIQNEKIRREYRKYVRQHAWLPKCLRCSKTSISSGIVSGNGGPGGVSGGVATNSAGTLSKSKSKLPLGSSDDGHDEEQPHQQQHQHDQPANEDAIIMGAGSDCELSEAQQRRTLKSGLLAGSLQPVTPVGAVVLERGTLRSTGMASVGHASPTSSAGSTHLIFAHKHQQQLQQQPGESYYHQPDYYSWKHPQAGGQREYYNNTGVPGGGGGVGVGGASPQQSHEVFYWTQKHNNQHGKKKRGGGAGAVPASPSGSLHSRVTPASQVLFYPSYKKTSGMKQPPPSAQQAYPHYAEALDPPNNAAYYQQQLQQQQQLRQQRQQQQQQQLSSDEEQAHLLHLQHQQRRAGGQQQLPAPPPHMAQYQQELLAQQQRQQYRNKHSNCDLSQGIGLGMNMGMGQGLGGDAYYNQGGGGSSNGGGVGGDGPVYEEILSNRNSDAQHYEVGDFDVDEVYNNSVGTGVFNSMRAAVAAGGSRYGGGSLSGGSVTSRNQQQQLQAKQKQPPRRCAADDDDDDDDDDDEYDDEVTAAEQLHDSVCDDEDNESDMDDDDTHGLPPQSDERMRRLMALQDEDFKRRFQRQQRKNGLPLDYGAPPQTSAGATIAHPIEHNGAVFGVSGGVGEGSMRGAYRQQQQQLNAKSPSARLAVNELFGHGNAGPPLPPANQTPAQKRQQLQKLSPQSTTSSSSHTSHSNLQQHSAPTHHHLQHQQPQLHHHQQQQQARNLSAMLDENNTVRCYLEPLAK

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias223-246Basic and acidic residues
Compositional bias247-269Polar residues
Compositional bias278-304Polar residues
Compositional bias1105-1125Basic and acidic residues
Compositional bias1516-1536Polar residues
Compositional bias1545-1562Acidic residues
Compositional bias1700-1756Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH916367
EMBL· GenBank· DDBJ
EDW02098.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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