B4F7B7 · DUS15_RAT
- ProteinDual specificity protein phosphatase 15
- GeneDusp15
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids236 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
May play a role in the regulation of oligodendrocyte differentiation. May play a role in the regulation of myelin formation (PubMed:27532821).
Involved in the regulation of Erk1/2 phosphorylation in Schwann cells; the signaling may be linked to the regulation of myelination (PubMed:27891578).
May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 (By similarity).
Involved in the regulation of Erk1/2 phosphorylation in Schwann cells; the signaling may be linked to the regulation of myelination (PubMed:27891578).
May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 (By similarity).
Catalytic activity
- H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 88 | Phosphocysteine intermediate | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | plasma membrane | |
Molecular Function | myosin phosphatase activity | |
Molecular Function | phosphatase activity | |
Molecular Function | protein tyrosine phosphatase activity | |
Molecular Function | protein tyrosine/serine/threonine phosphatase activity | |
Biological Process | negative regulation of transcription by RNA polymerase II | |
Biological Process | positive regulation of ERK1 and ERK2 cascade | |
Biological Process | regulation of oligodendrocyte differentiation | |
Biological Process | signal transduction |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDual specificity protein phosphatase 15
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionB4F7B7
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for initiator methionine, lipidation, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Lipidation | 2 | N-myristoyl glycine | ||||
Sequence: G | ||||||
Chain | PRO_0000440699 | 2-236 | Dual specificity protein phosphatase 15 | |||
Sequence: GNGMTKVLPGLYLGNFIDAKDPDQLGRNKITHIVSIHESPQPLLQDITYLRISVSDTPEVPIKKHFKECVHFIHSCRLNGGNCLVHCFAGISRSTTVVIAYVMTVTGLGWQEVLEAIKASRPIANPNPGFRQQLEEFGWANSQKLRRQLEERFGEIPFRDEEDLRALLPLCRRCRQGPGTSAPSATTASSAASEGTLQRLVPRSPRESHRPLPLLARVKQTFFCLPRCLSRKGGK |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Developmental stage
Expression increases during oligodendrocyte differentiation.
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 4-144 | Tyrosine-protein phosphatase | ||||
Sequence: GMTKVLPGLYLGNFIDAKDPDQLGRNKITHIVSIHESPQPLLQDITYLRISVSDTPEVPIKKHFKECVHFIHSCRLNGGNCLVHCFAGISRSTTVVIAYVMTVTGLGWQEVLEAIKASRPIANPNPGFRQQLEEFGWANSQ | ||||||
Region | 178-213 | Disordered | ||||
Sequence: GPGTSAPSATTASSAASEGTLQRLVPRSPRESHRPL | ||||||
Compositional bias | 180-198 | Polar residues | ||||
Sequence: GTSAPSATTASSAASEGTL |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length236
- Mass (Da)26,309
- Last updated2008-09-23 v1
- Checksum005CBEA2E68D64D1
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
M0RD87 | M0RD87_RAT | Dusp15 | 244 | ||
A0A8I5YCB5 | A0A8I5YCB5_RAT | Dusp15 | 251 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 180-198 | Polar residues | ||||
Sequence: GTSAPSATTASSAASEGTL |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AABR07054333 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH474050 EMBL· GenBank· DDBJ | EDL86031.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC168211 EMBL· GenBank· DDBJ | AAI68211.1 EMBL· GenBank· DDBJ | mRNA |