Comprehensive prognostic and immunological analysis of Ubiquitin Specific Peptidase 28 in pan-cancers and identification of its role in hepatocellular carcinoma cell lines.
Our work led to the identification of significant differences between USP25 and USP28 and provided the molecular basis for the development of new and highly specific anti-cancer drugs
We confirm oligomeric states of USP25 and USP28 in cells and show that modulating oligomerization affects substrate stabilization in accordance with in vitro activity data
Knockdown of USP28 enhanced the radiosensitivity of esophageal cancer cells by destabilizing c-Myc and enhancing the accumulation of HIF-1alpha. Therefore USP28 may serve as a novel therapeutic target to overcome esophageal cancer radioresistance.
Lack of USP28 promotes a more malignant state of breast cancer cells indicated by an epithelial-to-mesenchymal (EMT) transition elevated proliferation migration and angiogenesis as well as a decreased adhesion.
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