Downregulation of senescence-associated secretory phenotype by knockdown of secreted frizzled-related protein 4 contributes to the prevention of skin aging.
miR-103a and miR-103b had high complementarity and conservation modulated reporter gene expression through seed sequences in the 3'UTRs of CAV-1 and SFRP4 mRNA and negatively regulated their mRNA and protein levels
Elevated circulating levels of secreted frizzled-related protein 4 in relation to insulin resistance and androgens in women with polycystic ovary syndrome.
miR-943-3p accelerated the progression of airway inflammation and remodeling in allergic asthma via suppressing the activity of SFRP4 through Wnt signaling pathway in asthma patients and OVA-induced mice.
increased SFRP4 and ficolin-3 levels are significantly associated with gestational diabetes mellitus development and might be important risk factors for this pregnancy complication.
Serum SFRP-4 levels were significantly higher in the type 2 diabetes group compared to the impaired glucose tolerance and normal glucose tolerance groups.
Data suggest that factors derived from conditioned medium of adipose-derived mesenchymal stem cells and sFRP4 significantly decrease cell viability and cell migration of breast tumor cells; this is accompanied by enhanced apoptosis via inhibition of canonical Wnt signal transduction.
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