An HBV susceptibility variant of KNG1 modulates the therapeutic effects of interferons alpha and lambda1 in HBV infection by promoting MAVS lysosomal degradation.
A vicious positive feedback loop of des-Arg(9)-bradykinin- and bradykinin-mediated inflammation --> injury --> inflammation likely precipitates life threatening respiratory complications in COVID-19.
Data found that the serum BK levels and the levels of its receptor B2R were overexpressed in patients with cervical cancer (CC). BK promotes the development of CC may be the upregulation of VEGF expression thus accelerating angiogenesis through B2R.
KNG1 was identified as the core gene and lowly expressed in the glioma cells. Overexpression of KNG1 inhibited cell viability and angiogenesis of glioma cells. Overexpression of KNG1 promoted the apoptosis and G1 phase cell cycle arrest of glioma cells.
Three loci showed robust replicating association with circulating FXI levels: KNG1 (rs710446 P-value = 2.07 x 10-302) F11 (rs4253417 P-value = 2.86 x 10-193) and a novel association in GCKR (rs780094 P-value = 3.56 x10-09) here for the first time implicated in FXI regulation. The two first SNPs (rs710446 and rs4253417) also associated with partial thromboplastin time
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