NEDO human cDNA sequencing project focused on splicing variants.Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K.[...], Isogai T.Cited forNUCLEOTIDE SEQUENCETissueThymusCategoriesSequencesSourceUniProtKB unreviewed (TrEMBL)Submission Submitted to EMBL/GenBank/DDBJ databases (OCT-2007)Cited in399+
P2X7R Modulates NEK7-NLRP3 Interaction to Exacerbate Experimental Autoimmune Prostatitis via GSDMD-mediated Prostate Epithelial Cell Pyroptosis.Chen L., Liu Y., Yue S., Wang H., Chen J., Ma W., Xu W., Xu M., Chen Z.[...], Liang C.View abstractAnnotationP2X7R Modulates NEK7-NLRP3 Interaction to Exacerbate Experimental Autoimmune Prostatitis via GSDMD-mediated Prostate Epithelial Cell Pyroptosis.SourceGeneRif: 79792PubMedEurope PMCInt J Biol Sci 20:3393-3411 (2024)Mapped to16
Palmitoylation at a conserved cysteine residue facilitates gasdermin D- mediated pyroptosis and cytokine release.Liu Z., Li S., Wang C., Vidmar K.J., Bracey S., Li L., Willard B., Miyagi M., Lan T.[...], Xiao T.S.View abstractAnnotationPalmitoylation at a conserved cysteine residue facilitates gasdermin D-mediated pyroptosis and cytokine release.SourceGeneRif: 79792PubMedEurope PMCProc Natl Acad Sci U S A 121:e2400883121-e2400883121 (2024)Mapped to7
Targeting BRD4 mitigates hepatocellular lipotoxicity by suppressing the NLRP3 inflammasome activation and GSDMD-mediated hepatocyte pyroptosis.Chen F., Li S., Liu M., Qian C., Shang Z., Song X., Jiang W., Tu C.View abstractAnnotationTargeting BRD4 mitigates hepatocellular lipotoxicity by suppressing the NLRP3 inflammasome activation and GSDMD-mediated hepatocyte pyroptosis.SourceGeneRif: 79792PubMedEurope PMCCell Mol Life Sci 81:295-295 (2024)Mapped to23
Gasdermin D deficiency aborts myeloid calcium influx to drive granulopoiesis in lupus nephritis.Shen J., Li F., Han X., Fu D., Xu Y., Zhu C., Liang Z., Tang Z., Zheng R.[...], Yu X.View abstractAnnotationGasdermin D deficiency aborts myeloid calcium influx to drive granulopoiesis in lupus nephritis.SourceGeneRif: 79792PubMedEurope PMCCell Commun Signal 22:308-308 (2024)Mapped to7
Silent information regulator sirtuin 1 ameliorates acute liver failure <i>via</i> the p53/glutathione peroxidase 4/gasdermin D axis.Zhou X.N., Zhang Q., Peng H., Qin Y.J., Liu Y.H., Wang L., Cheng M.L., Luo X.H., Li H.View abstractAnnotationSilent information regulator sirtuin 1 ameliorates acute liver failure via the p53/glutathione peroxidase 4/gasdermin D axis.SourceGeneRif: 79792PubMedEurope PMCWorld J Gastroenterol 30:1588-1608 (2024)Mapped to99+
ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D.Du G., Healy L.B., David L., Walker C., El-Baba T.J., Lutomski C.A., Goh B., Gu B., Pi X.[...], Wu H.View abstractAnnotationROS-dependent S-palmitoylation activates cleaved and intact gasdermin D.SourceGeneRif: 79792PubMedEurope PMCNature 0:0-0 (2024)Cited in8Mapped to6
Targeting STING elicits GSDMD-dependent pyroptosis and boosts anti-tumor immunity in renal cell carcinoma.Wu S., Wang B., Li H., Wang H., Du S., Huang X., Fan Y., Gao Y., Gu L.[...], Ma X.View abstractAnnotationTargeting STING elicits GSDMD-dependent pyroptosis and boosts anti-tumor immunity in renal cell carcinoma.SourceGeneRif: 79792PubMedEurope PMCOncogene 43:1534-1548 (2024)Mapped to16
A palmitoylation-depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis.Zhang N., Zhang J., Yang Y., Shan H., Hou S., Fang H., Ma M., Chen Z., Tan L., Xu D.View abstractAnnotationA palmitoylation-depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis.SourceGeneRif: 79792PubMedEurope PMCNat. Cell Biol. 0:0-0 (2024)Cited in3Mapped to7
The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis.Balasubramanian A., Hsu A.Y., Ghimire L., Tahir M., Devant P., Fontana P., Du G., Liu X., Fabin D.[...], Luo H.R.View abstractAnnotationThe palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis.SourceGeneRif: 79792PubMedEurope PMCSci. Immunol. 9:eadn1452-eadn1452 (2024)Cited in6Mapped to6
TR4 worsen urosepsis by regulating GSDMD.Wang H., Zhu S., Zhou Z., Wang Z., Zhuang W., Xue D., Lu Z., Zheng Q., Ding L.[...], Wu H.View abstractAnnotationTR4 worsen urosepsis by regulating GSDMD.SourceGeneRif: 79792PubMedEurope PMCEur J Med Res 29:151-151 (2024)Mapped to16
Gasdermin D regulates soluble fms-like tyrosine kinase 1 release in macrophages.Tanaka H., Ozawa R., Henmi Y., Hosoda M., Karasawa T., Takahashi M., Takahashi H., Iwata H., Kuwayama T., Shirasuna K.View abstractAnnotationGasdermin D regulates soluble fms-like tyrosine kinase 1 release in macrophages.SourceGeneRif: 79792PubMedEurope PMCReprod Biol 24:100857-100857 (2024)Mapped to24
GSDMD suppresses keratinocyte differentiation by inhibiting FLG expression and attenuating KCTD6-mediated HDAC1 degradation in atopic dermatitis.Zhong Y., Huang T., Li X., Luo P., Zhang B.View abstractAnnotationGSDMD suppresses keratinocyte differentiation by inhibiting FLG expression and attenuating KCTD6-mediated HDAC1 degradation in atopic dermatitis.SourceGeneRif: 79792PubMedEurope PMCPeerJ 12:e16768-e16768 (2024)Mapped to7
Gasdermin D triggers cardiolipin-driven mitochondrial damage and pyroptosis.Cai Q., Shubhra Q.T.H.View abstractAnnotationGasdermin D triggers cardiolipin-driven mitochondrial damage and pyroptosis.SourceGeneRif: 79792PubMedEurope PMCTrends Immunol 45:75-77 (2024)Mapped to7
[Expressions of NLRP3, Caspase-1, and GSDMD in nasopharyngeal carcinoma tissue and association with recurrence and metastasis].Liu D., Wan L., Peng C., Cen R.X., Xu F.View abstractSourceGeneRif: 79792PubMedEurope PMCZhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 58:1215-1224 (2023)Mapped to24
O-GlcNAc modification of GSDMD attenuates LPS-induced endothelial cells pyroptosis.Yu F., Zhang Z., Leng Y., Chen A.F.View abstractAnnotationO-GlcNAc modification of GSDMD attenuates LPS-induced endothelial cells pyroptosis.CategoriesFunctionSourceGeneRif: 79792PubMedEurope PMCInflamm. Res. 73:5-17 (2024)Cited in3Mapped to6
System analysis based on the pyroptosis-related genes identifes GSDMD as a novel therapy target for skin cutaneous melanoma.Zhao S., Zhu Y., Liu H., He X., Xie J.View abstractAnnotationSystem analysis based on the pyroptosis-related genes identifes GSDMD as a novel therapy target for skin cutaneous melanoma.SourceGeneRif: 79792PubMedEurope PMCJ Transl Med 21:801-801 (2023)Mapped to7
CHMP4B and VSP4A reverse GSDMD-mediated pyroptosis by cell membrane remodeling in endometrial carcinoma.Yang Y., Chen H.L., Wu S.F., Bao W.View abstractAnnotationCHMP4B and VSP4A reverse GSDMD-mediated pyroptosis by cell membrane remodeling in endometrial carcinoma.SourceGeneRif: 79792PubMedEurope PMCBiochim Biophys Acta Gen Subj 1868:130497-130497 (2024)Mapped to16
Gasdermin D activation in oligodendrocytes and microglia drives inflammatory demyelination in progressive multiple sclerosis.Pollock N.M., Fernandes J.P., Woodfield J., Moussa E., Hlavay B., Branton W.G., Wuest M., Mohammadzadeh N., Schmitt L.[...], Power C.View abstractAnnotationGasdermin D activation in oligodendrocytes and microglia drives inflammatory demyelination in progressive multiple sclerosis.CategoriesFunctionSourceGeneRif: 79792PubMedEurope PMCBrain Behav Immun 115:374-393 (2024)Mapped to7
Expression and significance of effector proteins NLRP3 and gasdermin D N- terminal protein in the pyrolysis pathway in breast cancer.Wu L., Wu X., Liu J., Huang Y., Zhu Q.View abstractAnnotationExpression and significance of effector proteins NLRP3 and gasdermin D N-terminal protein in the pyrolysis pathway in breast cancer.CategoriesFamily & DomainsSourceGeneRif: 79792PubMedEurope PMCMedicine (Baltimore) 102:e35440-e35440 (2023)Mapped to14
Gasdermin D (GSDMD) Is Upregulated in Psoriatic Skin-A New Potential Link in the Pathogenesis of Psoriasis.Nowowiejska J., Baran A., Hermanowicz J.M., Pryczynicz A., Sieklucka B., Pawlak D., Flisiak I.View abstractAnnotationGasdermin D (GSDMD) Is Upregulated in Psoriatic Skin-A New Potential Link in the Pathogenesis of Psoriasis.CategoriesFunctionSourceGeneRif: 79792PubMedEurope PMCInt J Mol Sci 24:13047-13047 (2023)Mapped to7
Gasdermin D Plays an Oncogenic Role in Glioma and Correlates to an Immunosuppressive Microenvironment.Li M., Jiang P., Wei S., Yang Y., Xiong L., Wang J., Li C.View abstractAnnotationGasdermin D Plays an Oncogenic Role in Glioma and Correlates to an Immunosuppressive Microenvironment.CategoriesFunctionSourceGeneRif: 79792PubMedEurope PMCBiomolecules 13:904-904 (2023)Mapped to7
Gasdermin D-mediated pyroptosis: mechanisms, diseases, and inhibitors.Dai Z., Liu W.C., Chen X.Y., Wang X., Li J.L., Zhang X.View abstractAnnotationGasdermin D-mediated pyroptosis: mechanisms diseases and inhibitors.CategoriesFunctionSourceGeneRif: 79792PubMedEurope PMCFront Immunol 14:1178662-1178662 (2023)Mapped to7
The Role of Gasdermin-D-Mediated Pyroptosis in Organ Injury and Its Therapeutic Implications.Mulla J., Katti R., Scott M.J.View abstractAnnotationThe Role of Gasdermin-D-Mediated Pyroptosis in Organ Injury and Its Therapeutic Implications.SourceGeneRif: 79792PubMedEurope PMCOrganogenesis 19:2177484-2177484 (2023)Mapped to7
GSDMD-mediated pyroptosis promotes cardiac remodeling in pressure overload.You J., Li X., Dai F., Liu J., Zhang Q., Guo W.View abstractAnnotationGSDMD-mediated pyroptosis promotes cardiac remodeling in pressure overload.CategoriesFunctionSourceGeneRif: 79792PubMedEurope PMCClin Exp Hypertens 45:2189138-2189138 (2023)Mapped to7