B4E0T0 · B4E0T0_HUMAN

  • Protein
    cDNA FLJ51589, highly similar to Neutrophil collagenase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    2/5

Function

Cofactor

Protein has several cofactor binding sites:
Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Can bind about 5 Ca2+ ions per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Features

Showing features for binding site, active site.

130520406080100120140160180200220240260280300
TypeIDPosition(s)Description
Binding site26Zn2+ 2 (UniProtKB | ChEBI); catalytic; in inhibited form
Binding site92Ca2+ 2 (UniProtKB | ChEBI)
Binding site102Zn2+ 1 (UniProtKB | ChEBI)
Binding site104Zn2+ 1 (UniProtKB | ChEBI)
Binding site109Ca2+ 3 (UniProtKB | ChEBI)
Binding site110Ca2+ 3 (UniProtKB | ChEBI)
Binding site117Zn2+ 1 (UniProtKB | ChEBI)
Binding site126Ca2+ 2 (UniProtKB | ChEBI)
Binding site128Ca2+ 2 (UniProtKB | ChEBI)
Binding site130Zn2+ 1 (UniProtKB | ChEBI)
Binding site132Ca2+ 3 (UniProtKB | ChEBI)
Binding site135Ca2+ 1 (UniProtKB | ChEBI)
Binding site135Ca2+ 3 (UniProtKB | ChEBI)
Binding site152Zn2+ 2 (UniProtKB | ChEBI); catalytic
Active site153
Binding site156Zn2+ 2 (UniProtKB | ChEBI); catalytic
Binding site162Zn2+ 2 (UniProtKB | ChEBI); catalytic
Binding site170Zn2+ 2 (UniProtKB | ChEBI); catalytic
Binding site221Ca2+ 4 (UniProtKB | ChEBI)
Binding site223Ca2+ 5 (UniProtKB | ChEBI)
Binding site267Ca2+ 5 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcollagen trimer
Cellular Componentextracellular matrix
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processproteolysis

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Submitted names
    • cDNA FLJ51589, highly similar to Neutrophil collagenase

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    B4E0T0

Subcellular Location

PTM/Processing

Keywords

Proteomic databases

Family & Domains

Features

Showing features for domain, repeat.

TypeIDPosition(s)Description
Domain39-198Peptidase metallopeptidase
Repeat211-260Hemopexin

Sequence similarities

Belongs to the peptidase M10A family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    305
  • Mass (Da)
    34,593
  • Last updated
    2008-09-23 v1
  • Checksum
    01138C2CE4B1DD4E
MQRFFGLNVTGKPNEETLDMMEKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKDMITKDNSWSQVIPKAYQVPFRNRE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK303511
EMBL· GenBank· DDBJ
BAG64542.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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