IPO5 is an oncogene involved in CRC cell proliferation and migration. This highlights the significance of IPO5 in 5-fluorouracil-resistant CRC cells. The oncogenic function of IPO5 was mediated by promoting RAS signalling by increasing the nuclear translocation of RASAL2
Results indicate that the interaction between FLIL33 and IPO5 is localized to a specific segment of the FLIL33 protein is not required for nuclear localization of FLIL33 and protects FLIL33 from proteasome-dependent degradation.
The nuclear importin IPO5 was identified as a novel interacting protein of SMAD1. Overexpression of IPO5 in various cell lines specifically increases nuclear localization of BMP receptor-activated SMADs (R-SMADs) confirming a functional relationship between IPO5 and BMP but not TGF-beta R-SMADs.
Importins Impbeta Kapbeta2 Imp4 Imp5 Imp7 Imp9 and Impalpha show the H3 tail binding more tightly than the H4 tail. The H3 tail binds Kapbeta2 and Imp5 with KD values of 77 and 57 nm respectively and binds the other five Importins more weakly.
importin beta3 is essential for the nuclear import of RPL7. The import is mediated via the multifaceted basic amino acid clusters present in the NH(2)-region of RPL7 and is RanGTP-dependent
The results of this study suggested that abnormal expression and alternative splicing of the IPO5 gene may be involved in the pathophysiology of schizophrenia; Observational study of gene-disease association. (HuGE Navigator)
The present work suggests that the combination of the KPNA3 gene and the KPNB3 gene may increase a genetic risk for schizophrenia; Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
HPV16 L2 interacts via its NLSs with a network of karyopherins and can enter the nucleus via several import pathways mediated by Kapalpha(2)beta(1) heterodimers Kapbeta(2) and Kapbeta(3).
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