CENPI is overexpressed in colorectal cancer (CRC) and functions as oncogene in modulating CRC cell migration invasion and epithelial-mesenchymal transition process.
mutation in LRPAP1 is associated with high myopia. Further studies are expected to evaluate the pathogenicity of the variants in CTSH LEPREL1 ZNF644 SLC39A5 and SCO2.
We conclude that the dual activities of Aurora B and CENP-I generate a molecular switch that maintains a robust spindle checkpoint signal at prometaphase kinetochores until they attain mature attachments to microtubules.
demonstrates that CENPI a centromere protein that localizes to the inner kinetochore structure is a human autoantigen. The significance of anti-CENPI autoantibodies could be relevant in scleroderma patients as a marker for autoimmune liver disease
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.