Conserved sequence motifs in human TMTC1 TMTC2 TMTC3 and TMTC4 new O-mannosyltransferases from the GT-C/PMT clan are rationalized as ligand binding sites.
SMILE is a novel transgene specifying both bronchial smooth muscle and lung alveolar myofibroblast lineages contributing to the understanding of the biological control of the development of these cells.
that SMILE is involved in the endoplasmic reticulum stress response by modulating proteasome activity and XBP-1 transcript expression. This function of SMILE may influence immune cell behavior in the context of transplantation.
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