Study identify MED12 as an important molecular regulator of epithelial ovarian cancer (EOC) tumor dormancy. MED12 knockout (KO) induced dormancy of EOC cells in vitro and in vivo and microarray analysis showed that MED12 KO decreased expression of EGFR. MED12 bound to the promoter of EGFR and MED12 expression positively correlated with EGFR expression in EOC patient samples.
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