NEDO human cDNA sequencing project focused on splicing variants.Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K.[...], Isogai T.Cited forNUCLEOTIDE SEQUENCETissueTestisCategoriesSequencesSourceUniProtKB unreviewed (TrEMBL)Submission Submitted to EMBL/GenBank/DDBJ databases (OCT-2007)Cited in399+
Interaction between MED12 and DeltaNp63 activates basal identity in pancreatic ductal adenocarcinoma.Maia-Silva D., Cunniff P.J., Schier A.C., Skopelitis D., Trousdell M.C., Moresco P., Gao Y., Kechejian V., He X.Y.[...], Vakoc C.R.View abstractAnnotationInteraction between MED12 and DeltaNp63 activates basal identity in pancreatic ductal adenocarcinoma.SourceGeneRif: 9968PubMedEurope PMCNat Genet 56:1377-1385 (2024)Mapped to17
The Effect of Race/Ethnicity and MED12 Mutation on the Expression of Long Non-Coding RNAs in Uterine Leiomyoma and Myometrium.Chuang T.D., Ton N., Rysling S., Boos D., Khorram O.View abstractAnnotationThe Effect of Race/Ethnicity and MED12 Mutation on the Expression of Long Non-Coding RNAs in Uterine Leiomyoma and Myometrium.CategoriesFunctionSourceGeneRif: 9968PubMedEurope PMCInt J Mol Sci 25:1307-1307 (2024)Mapped to9
Novel pathogenic variant in MED12 causing non-syndromic dilated cardiomyopathy.Ghasemi S., Mahdavi M., Maleki M., Salahshourifar I., Kalayinia S.View abstractAnnotationNovel pathogenic variant in MED12 causing non-syndromic dilated cardiomyopathy.CategoriesFunctionSourceGeneRif: 9968PubMedEurope PMCBMC Med Genomics 16:334-334 (2023)Mapped to9
RISING STARS: Role of MED12 mutation in the pathogenesis of uterine fibroids.Ishikawa H., Kobayashi T., Kaneko M., Saito Y., Shozu M., Koga K.View abstractAnnotationRISING STARS: Role of MED12 mutation in the pathogenesis of uterine fibroids.CategoriesFunctionSourceGeneRif: 9968PubMedEurope PMCJ Mol Endocrinol 71:e230039-e230039 (2023)Mapped to9
The Mediator Complex Subunit 12 (MED-12) Gene and Uterine Fibroids: a Systematic Review.Amendola I.L.S., Spann M., Segars J., Singh B.View abstractAnnotationThe Mediator Complex Subunit 12 (MED-12) Gene and Uterine Fibroids: a Systematic Review.CategoriesExpressionSourceGeneRif: 9968PubMedEurope PMCReprod Sci 31:291-308 (2024)Mapped to9
MED12 variants associated with X-linked recessive partial epilepsy without intellectual disability.Yang J.H., Liu Z.G., Liu C.L., Zhang M.R., Jia Y.L., Zhai Q.X., He M.F., He N., Qiao J.D.View abstractAnnotationMED12 variants associated with X-linked recessive partial epilepsy without intellectual disability.SourceGeneRif: 9968PubMedEurope PMCSeizure 116:30-36 (2024)Mapped to9
Differential Expression of MED12-Associated Coding RNA Transcripts in Uterine Leiomyomas.Chuang T.D., Gao J., Quintanilla D., McSwiggin H., Boos D., Yan W., Khorram O.View abstractAnnotationDifferential Expression of MED12-Associated Coding RNA Transcripts in Uterine Leiomyomas.CategoriesExpressionSourceGeneRif: 9968PubMedEurope PMCInt J Mol Sci 24:3742-3742 (2023)Mapped to9
XLID syndrome gene Med12 promotes Ig isotype switching through chromatin modification and enhancer RNA regulation.Haque F., Honjo T., Begum N.A.View abstractAnnotationXLID syndrome gene Med12 promotes Ig isotype switching through chromatin modification and enhancer RNA regulation.CategoriesFunctionSourceGeneRif: 9968PubMedEurope PMCSci Adv 8:eadd1466-eadd1466 (2022)Mapped to9
MED12 mutation as a potential predictive biomarker for immune checkpoint inhibitors in pan-cancer.Zhou Y., Tan Y., Zhang Q., Duan Q., Chen J.View abstractAnnotationMED12 mutation as a potential predictive biomarker for immune checkpoint inhibitors in pan-cancer.CategoriesFunction, Disease & VariantsSourceGeneRif: 9968PubMedEurope PMCEur J Med Res 27:225-225 (2022)Mapped to9
Missense MED12 variants in 22 males with intellectual disability: From nonspecific symptoms to complete syndromes.Maia N., Ibarluzea N., Misra-Isrie M., Koboldt D.C., Marques I., Soares G., Santos R., Marcelis C.L.M., Keski-Filppula R.[...], de Brouwer A.P.M.View abstractAnnotationMissense MED12 variants in 22 males with intellectual disability: From nonspecific symptoms to complete syndromes.CategoriesSequencesSourceGeneRif: 9968PubMedEurope PMCAm J Med Genet A 191:135-143 (2023)Mapped to9
MED12 mutations in uterine leiomyomas: prediction of volume reduction by gonadotropin-releasing hormone agonists.Nagai K., Asano R., Sekiguchi F., Asai-Sato M., Miyagi Y., Miyagi E.View abstractAnnotationMED12 mutations in uterine leiomyomas: prediction of volume reduction by gonadotropin-releasing hormone agonists.CategoriesSequencesSourceGeneRif: 9968PubMedEurope PMCAm J Obstet Gynecol 228:207.e1-207.e9 (2023)Mapped to9
A mediator complex subunit 12 gain-of-function mutation induces partial leiomyoma cell properties in human uterine smooth muscle cells.Takao T., Ono M., Yoshimasa Y., Masuda H., Maruyama T.View abstractAnnotationA mediator complex subunit 12 gain-of-function mutation induces partial leiomyoma cell properties in human uterine smooth muscle cells.CategoriesFunctionSourceGeneRif: 9968PubMedEurope PMCF S Sci 3:288-298 (2022)Mapped to9
Different DNA methylome, transcriptome and histological features in uterine fibroids with and without MED12 mutations.Maekawa R., Sato S., Tamehisa T., Sakai T., Kajimura T., Sueoka K., Sugino N.View abstractAnnotationDifferent DNA methylome transcriptome and histological features in uterine fibroids with and without MED12 mutations.CategoriesFunctionSourceGeneRif: 9968PubMedEurope PMCSci Rep 12:8912-8912 (2022)Mapped to9
The novel mechanism of Med12-mediated drug resistance in a TGFBR2- independent manner.Han Y., Dong Q., Liu T., Chen X., Yu C., Zhang Y.View abstractAnnotationThe novel mechanism of Med12-mediated drug resistance in a TGFBR2-independent manner.CategoriesFunctionSourceGeneRif: 9968PubMedEurope PMCBiochem Biophys Res Commun 610:1-7 (2022)Mapped to22
MED12 Regulates Smooth Muscle Cell Functions and Participates in the Development of Aortic Dissection.Zhou Y., Zha L., Wu J., Wang M., Zhou M., Wu G., Cheng X., Huang Z., Xie Q., Tu X.View abstractAnnotationMED12 Regulates Smooth Muscle Cell Functions and Participates in the Development of Aortic Dissection.CategoriesFunctionSourceGeneRif: 9968PubMedEurope PMCGenes (Basel) 13:692-692 (2022)Mapped to9
Aberrant R-loop-induced replication stress in MED12-mutant uterine fibroids.Muralimanoharan S., Shamby R., Stansbury N., Schenken R., de la Pena Avalos B., Javanmardi S., Dray E., Sung P., Boyer T.G.View abstractAnnotationAberrant R-loop-induced replication stress in MED12-mutant uterine fibroids.CategoriesFunctionSourceGeneRif: 9968PubMedEurope PMCSci Rep 12:6169-6169 (2022)Mapped to9
A Mediator-cohesin axis controls heterochromatin domain formation.Haarhuis J.H.I., van der Weide R.H., Blomen V.A., Flach K.D., Teunissen H., Willems L., Brummelkamp T.R., Rowland B.D., de Wit E.View abstractAnnotationA Mediator-cohesin axis controls heterochromatin domain formation.CategoriesFunctionSourceGeneRif: 9968PubMedEurope PMCNat Commun 13:754-754 (2022)Mapped to23
X-linked Ohdo syndrome due to a novel MED12 variant detected by Rapid Exome Sequencing.McDermott H., Garikapati V., Baptista J., Gowda H., Naik S.AnnotationX-linked Ohdo syndrome due to a novel MED12 variant detected by Rapid Exome Sequencing.CategoriesFunction, SequencesSourceGeneRif: 9968PubMedEurope PMCClin Dysmorphol 31:101-105 (2022)Mapped to9
MED12 is overexpressed in glioblastoma patients and serves as an oncogene by targeting the VDR/BCL6/p53 axis.Srivastava S., Makala H., Sharma V., Suri V., Sarkar C., Kulshreshtha R.View abstractAnnotationMED12 is overexpressed in glioblastoma patients and serves as an oncogene by targeting the VDR/BCL6/p53 axis.CategoriesFunction, InteractionSourceGeneRif: 9968PubMedEurope PMCCell Mol Life Sci 79:104-104 (2022)Mapped to21
Tryptophan 2,3-Dioxygenase-2 in Uterine Leiomyoma: Dysregulation by MED12 Mutation Status.Hutchinson A.P., Yin P., Neale I., Coon J.S., Kujawa S.A., Liu S., Bulun S.E.View abstractAnnotationTryptophan 2 3-Dioxygenase-2 in Uterine Leiomyoma: Dysregulation by MED12 Mutation Status.CategoriesFunctionSourceGeneRif: 9968PubMedEurope PMCReprod Sci 29:743-749 (2022)Mapped to9
MED12 Regulates Human Adipose-Derived Stem Cell Adipogenesis and Mediator Kinase Subunit Expression in Murine Adipose Depots.Venigalla S., Straub J., Idigo O., Rinderle C., Stephens J.M., Newman J.J.View abstractAnnotationMED12 Regulates Human Adipose-Derived Stem Cell Adipogenesis and Mediator Kinase Subunit Expression in Murine Adipose Depots.CategoriesFunctionSourceGeneRif: 9968PubMedEurope PMCStem Cells Dev 31:119-131 (2022)Mapped to12
MED12 and BRD4 cooperate to sustain cancer growth upon loss of mediator kinase.Sooraj D., Sun C., Doan A., Garama D.J., Dannappel M.V., Zhu D., Chua H.K., Mahara S., Wan Hassan W.A.[...], Firestein R.View abstractAnnotationMED12 and BRD4 cooperate to sustain cancer growth upon loss of mediator kinase.CategoriesFunctionSourceGeneRif: 9968PubMedEurope PMCMol Cell 82:123-139.e7 (2022)Mapped to28
Loss of MED12 activates the TGFbeta pathway to promote chemoresistance and replication fork stability in BRCA-deficient cells.Jackson L.M., Dhoonmoon A., Hale A., Dennis K.A., Schleicher E.M., Nicolae C.M., Moldovan G.L.View abstractAnnotationLoss of MED12 activates the TGFbeta pathway to promote chemoresistance and replication fork stability in BRCA-deficient cells.CategoriesFunctionSourceGeneRif: 9968PubMedEurope PMCNucleic Acids Res 49:12855-12869 (2021)Mapped to25
Eye and ocular adnexa manifestations of <i>MED12</i>-related disorders.Shah A., Bapna M., Al-Saif H., Li R., Couser N.L.View abstractAnnotationEye and ocular adnexa manifestations of MED12-related disorders.CategoriesSequencesSourceGeneRif: 9968PubMedEurope PMCOphthalmic Genet 43:126-129 (2022)Mapped to9