B4DY26 · B4DY26_HUMAN
- ProteinTGF-beta receptor type-1
- GeneTGFBR1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids434 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
Catalytic activity
- ATP + L-seryl-[receptor-protein] = ADP + H+ + O-phospho-L-seryl-[receptor-protein]
Cofactor
Protein has several cofactor binding sites:
Features
Showing features for binding site.
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTGF-beta receptor type-1
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionB4DY26
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 57-78 | Helical | ||||
Sequence: LAAVIAGPVCFVCISLMLMVYI |
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,094 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Modified residue (large scale data) | 96 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 113 | PRIDE | Phosphotyrosine | ||||
Sequence: Y |
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 106-135 | GS | ||||
Sequence: TTLKDLIYDMTTSGSGSGLPLLVQRTIART | ||||||
Domain | 136-426 | Protein kinase | ||||
Sequence: IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQL |
Sequence similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length434
- Mass (Da)48,875
- Last updated2008-09-23 v1
- Checksum238B50CE9BDA2BB0
Computationally mapped potential isoform sequences
There are 13 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P36897 | TGFR1_HUMAN | TGFBR1 | 503 | ||
A0AAQ5BHZ0 | A0AAQ5BHZ0_HUMAN | TGFBR1 | 118 | ||
A0AAQ5BHT0 | A0AAQ5BHT0_HUMAN | TGFBR1 | 477 | ||
A0AAQ5BHT5 | A0AAQ5BHT5_HUMAN | TGFBR1 | 48 | ||
A0AAQ5BHY0 | A0AAQ5BHY0_HUMAN | TGFBR1 | 70 | ||
A0AAQ5BHY8 | A0AAQ5BHY8_HUMAN | TGFBR1 | 67 | ||
A0AAQ5BHW0 | A0AAQ5BHW0_HUMAN | TGFBR1 | 49 | ||
A0AAQ5BI21 | A0AAQ5BI21_HUMAN | TGFBR1 | 502 | ||
F8VXZ5 | F8VXZ5_HUMAN | TGFBR1 | 357 | ||
F8VRH6 | F8VRH6_HUMAN | TGFBR1 | 255 | ||
F8W0K6 | F8W0K6_HUMAN | TGFBR1 | 438 | ||
F8W1R9 | F8W1R9_HUMAN | TGFBR1 | 383 | ||
A0A8V8TMI6 | A0A8V8TMI6_HUMAN | TGFBR1 | 50 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL162427 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AK302234 EMBL· GenBank· DDBJ | BAG63588.1 EMBL· GenBank· DDBJ | mRNA |