B4DWX6 · B4DWX6_HUMAN
- ProteinMedium-chain specific acyl-CoA dehydrogenase, mitochondrial
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids385 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Catalytic activity
- H+ + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]This reaction proceeds in the forward direction.
- H+ + hexanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]This reaction proceeds in the forward direction.
- H+ + octanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein]This reaction proceeds in the forward direction.
- H+ + oxidized [electron-transfer flavoprotein] + pentanoyl-CoA = (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]This reaction proceeds in the forward direction.
- H+ + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]This reaction proceeds in the forward direction.
- decanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = (2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein]This reaction proceeds in the forward direction.
- dodecanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]This reaction proceeds in the forward direction.
Cofactor
Pathway
Lipid metabolism; mitochondrial fatty acid beta-oxidation.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 155-157 | FAD (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain | ||||
Sequence: WIT | ||||||
Binding site | 270-272 | FAD (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain | ||||
Sequence: RKT | ||||||
Binding site | 280-281 | FAD (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain | ||||
Sequence: HQ | ||||||
Binding site | 338-342 | FAD (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain | ||||
Sequence: QILGG | ||||||
Active site | 365 | Proton acceptor | ||||
Sequence: E | ||||||
Binding site | 367-369 | FAD (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain | ||||
Sequence: TSQ |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial matrix | |
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | medium-chain fatty acyl-CoA dehydrogenase activity | |
Biological Process | fatty acid beta-oxidation | |
Biological Process | medium-chain fatty acid catabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMedium-chain specific acyl-CoA dehydrogenase, mitochondrial
- EC number
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionB4DWX6
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 6-115 | Acyl-CoA dehydrogenase/oxidase N-terminal | ||||
Sequence: TEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTE | ||||||
Domain | 121-219 | Acyl-CoA oxidase/dehydrogenase middle | ||||
Sequence: AYCVTEPGAGFDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDV | ||||||
Domain | 231-378 | Acyl-CoA dehydrogenase/oxidase C-terminal | ||||
Sequence: GAGFKVAMGAFDKTRPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVARE |
Sequence similarities
Belongs to the acyl-CoA dehydrogenase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length385
- Mass (Da)42,487
- Last updated2008-09-23 v1
- Checksum73DDCD3D91A6286C