soluble HLA-Ib molecules HLA-G and HLA-E are present in BM plasma samples in physiological and pathological conditions and their concentration correlated with stage disease in NB patients.
In insulitic islets from living patients with recent-onset T1D most of the overexpressed ISGs including GBP1 TLR3 OAS1 EIF2AK2 HLA-E IFI6 and STAT1 showed higher expression in the islet core compared with the peri-islet area containing the surrounding immune cells
this study shows the high expression of HLA-E in actinic chelitis and in lip squamous cell carcinoma which reflects the capacity that these pathologies have for evasion and progression
childhood acute lymphoblastic leukaemic patients but not healthy controls exhibited B cell populations with very low HLA-C and -E expression levels that could be consistently allocated to the CD19+CD45- leukaemic subset
relative expression levels of HLA-A HLA-B HLA-C and HLA-E proteins for the specific haplotype A*02:01 B*44:02 C*05:01 which were characterized using two independent methods based on flow cytometry and mass spectrometry.
The expression levels of HLA-G or HLA-E alone and the combined expression of both molecules were all statistically correlated with the overall survival of colorectal cancer patients.
the results suggest that the HLA-E and HLA-C molecules may play an important role in determination immune response contributing to the Psoriatic arthritis development.
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